发明公开
- 专利标题： COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE
- 专利标题（中）： 化合物作为蛋白法尼基转移酶抑制剂
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申请号： EP98926276.1申请日： 1998-06-15
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公开(公告)号： EP0993459A1公开(公告)日： 2000-04-19
- 发明人: REMISZEWSKI, Stacy, W. , DOLL, Ronald, J. , ALVAREZ, Carmen
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road KenilworthNew Jersey 07033 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road KenilworthNew Jersey 07033 US
- 代理机构： Ritter, Stephen David
- 优先权： US877739 19970617
- 国际公布： WO9857955 19981223
- 主分类号： C07D401/08
- IPC分类号： C07D401/08 ; C07D405/14 ; A61K31/55 ; C07D491/113 ; C07D495/10 ; C07D413/14 ; C07F7/18
摘要：
Novel compounds of formula (1.0) are disclosed. In formula (1.0) a represents N or NO, R?1 and R3¿ are halo, R?2 and R4¿ are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
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