发明公开
EP0995758A1 PHYSIOLOGICALLY ACTIVE POLYOXYPEPTIN AND DEOXYPOLYOXYPEPTIN AND ANTICANCER DRUGS CONTAINING THE SAME
失效
生物化学活性多羟基磷酸酯脱氧吡咯烷酮SOWIE DIESE ENTHALTENDE KREBSMITTEL
- 专利标题： PHYSIOLOGICALLY ACTIVE POLYOXYPEPTIN AND DEOXYPOLYOXYPEPTIN AND ANTICANCER DRUGS CONTAINING THE SAME
- 专利标题（中）： 生物化学活性多羟基磷酸酯脱氧吡咯烷酮SOWIE DIESE ENTHALTENDE KREBSMITTEL
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申请号： EP98924597.2申请日： 1998-06-12
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公开(公告)号： EP0995758A1公开(公告)日： 2000-04-26
- 发明人: TAKEUCHI, Tomio, New Fuji Mansion 701 , UMEZAWA, Kazuo , KONDO, Shinichi, Royal Heights Minami-Rokugo 608 , IKEDA, Yoko, Crescent Ikejiri Ohashi 502 , NAGANAWA, Hiroshi , HAMADA, Masa
- 申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 申请人地址： 14-23, Kami Osaki 3-chome Shinagawa-ku, Tokyo 141 JP
- 专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人地址： 14-23, Kami Osaki 3-chome Shinagawa-ku, Tokyo 141 JP
- 代理机构： Risku, Ira Marjatta
- 优先权： JP15664997 19970613; JP25508497 19970919
- 国际公布： WO9856809 19981217
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C12P21/04 ; C12N1/20 ; A61K38/12
摘要：
As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I)
wherein R denotes a hydroxyl group for polyoxypeptin, or R denotes a hydrogen atom for deoxypolyoxypeptin, by cultivation of Streptomyces sp. MK498-98F14 strain. Polyoxypeptin and deoxypolyoxypeptin are physiologically active substances which have an activity of inducing apoptosis on a human pancreatic adenocarcinoma cell, AsPC-1 cell.
wherein R denotes a hydroxyl group for polyoxypeptin, or R denotes a hydrogen atom for deoxypolyoxypeptin, by cultivation of Streptomyces sp. MK498-98F14 strain. Polyoxypeptin and deoxypolyoxypeptin are physiologically active substances which have an activity of inducing apoptosis on a human pancreatic adenocarcinoma cell, AsPC-1 cell.
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