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公开(公告)号：EP1211259B1
公开(公告)日：2003-11-19
申请号：EP00951962.0
申请日：2000-08-11
IPC分类号： C07H19/067 , C12P17/16 , C12N1/20 , A61K31/7072 , A61P31/04
CPC分类号： C07H19/06 , C12P17/16 , Y10S435/886
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公开(公告)号：EP1285928B1
公开(公告)日：2005-05-18
申请号：EP01917554.6
申请日：2001-03-28
发明人： TAKEUCHI, Tomio, New Fuji Mansion 701 , HASHIZUME, Hideki , IGARASHI, Masayuki , NAGANAWA, Hiroshi , HAMADA, Masa
摘要： By culturing Lysobacter sp. BMK333-48F3 (Accession No. FERM BP-7477), antibiotics tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C and tripropeptin D represented by general formula (I) are obtained as antibiotics showing an excellent antibacterial effect on bacteria and having a novel molecular skeleton, wherein R represents 7-methyl-octyl, 8-methyl-nonyl, 9-methyl-decyl, 10-methyl-undecyl or 11-methyl-dodecyl. These tripropeptins have an excellent antibacterial activity on various bacteria and drug-tolerant strains thereof such as methicillin-tolerant strains and vancomycin-tolerant strains.
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3.发明公开NOVEL ANTIBIOTICS WITH IMMUNOSUPPRESSIVE ACTIVITY, DELAMINOMYCINS, AND PRODUCTION THEREOF 失效使用抗生素麻省理工学院免疫印度尼西亚，德国HERSTELLUNG的DELAMINOMYCINE。
公开(公告)号：EP0647625A1
公开(公告)日：1995-04-12
申请号：EP93913563.8
申请日：1993-06-22
发明人： ISHIZUKA, Masaaki , UENO, Mitsuhiro , IINUMA, Hironobu , NAGANAWA, Hiroshi , HAMADA, Masa , MAEDA, Kenji , TAKEUCHI, Tomio
IPC分类号： C07D207/36 , C07D209/96 , C12P17/10 , A61K31/40 , C07D207/40
CPC分类号： C07D207/38 , C07D207/36 , C07D209/96 , C12P17/10
摘要： Delaminomycins A, B and C, represented by general formula (I) or (I'), or salts thereof, delaminomycins A2, B2 and C2, represented by general formula (II), and sulfates of delaminomycins A2 to C2, represented by general formula (III), or salts thereof. The delaminomycins selectively inhibit T cells, have the activity of inhibiting the growth of certain cancer cells, and are antibacterial.
摘要翻译： 由通式（I）或（I'）表示的Delaminomycins A，B和C或其盐，由通式（II）表示的脱氨基霉素A2，B2和C2，以及由一般式（II）表示的脱氨霉素A2至C2的硫酸盐 式（III）或其盐。 去霉素选择性抑制T细胞，具有抑制某些癌细胞生长的活性，并且是抗菌的。
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4.发明授权COMPOSITIONS FOR TREATING OR PREVENTING MALARIA AND METHOD OF TREATING MALARIA 有权混合物用于治疗疟疾的治疗或预防疟疾和方法
公开(公告)号：EP1295881B1
公开(公告)日：2008-10-08
申请号：EP01925951.4
申请日：2001-04-26
发明人： TAKEUCHI, Tomio, New Fuji Mansion 701 , WATAYA, Yusuke , IINUMA, Munekazu , KIM, Hye-Sook , WATABE, Hiroomi , NAGANAWA, Hiroshi , TAKAHASHI, Yoshikazu
IPC分类号： C07D407/14 , A61K31/351 , A61P33/06
CPC分类号： C07D407/14 , A61K31/351 , Y02A50/411
摘要： An antibiotic SF2487 substance having the formula (I) or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an antimalarial drug.
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5.发明公开ANTIBIOTIC CAPRAZAMYCINS AND PROCESS FOR PRODUCING THE SAME 有权抗生素CAPRAZAMYCINE UND VERFAHREN ZU DEREN HERSTELLUNG
公开(公告)号：EP1211259A1
公开(公告)日：2002-06-05
申请号：EP00951962.0
申请日：2000-08-11
IPC分类号： C07H19/067 , C12P17/16 , C12N1/20 , A61K31/7072 , A61P31/04
CPC分类号： C07H19/06 , C12P17/16 , Y10S435/886
摘要： There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I)
wherein R is tridecyl group, 11-methyl-dodecyl group, and others. These caprazamycins have excellent antibacterial activities against various acid-fast bacteria and various bacteria as well as their drug-resistant strains.摘要翻译： 已经通过培养链霉菌（Streptomyces sp。 MK730-62F2（FERM BP-7218的保藏号），具有以下通式（I）
的抗生素caprazamycins A至F，其中R为十三烷基，11-甲基 - 十二烷基等。 这些caprazamycins对各种耐酸细菌和各种细菌以及耐药菌株具有优异的抗菌活性。 -
6.发明公开PHYSIOLOGICALLY ACTIVE POLYOXYPEPTIN AND DEOXYPOLYOXYPEPTIN AND ANTICANCER DRUGS CONTAINING THE SAME 失效生物化学活性多羟基磷酸酯脱氧吡咯烷酮SOWIE DIESE ENTHALTENDE KREBSMITTEL
公开(公告)号：EP0995758A1
公开(公告)日：2000-04-26
申请号：EP98924597.2
申请日：1998-06-12
发明人： TAKEUCHI, Tomio, New Fuji Mansion 701 , UMEZAWA, Kazuo , KONDO, Shinichi, Royal Heights Minami-Rokugo 608 , IKEDA, Yoko, Crescent Ikejiri Ohashi 502 , NAGANAWA, Hiroshi , HAMADA, Masa
摘要： As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I)
wherein R denotes a hydroxyl group for polyoxypeptin, or R denotes a hydrogen atom for deoxypolyoxypeptin, by cultivation of Streptomyces sp. MK498-98F14 strain. Polyoxypeptin and deoxypolyoxypeptin are physiologically active substances which have an activity of inducing apoptosis on a human pancreatic adenocarcinoma cell, AsPC-1 cell.摘要翻译： 作为具有诱导细胞凋亡抗性的癌细胞的细胞凋亡的活性的新物质，可以举出以下通式（I）表示的多羟脯氨酸和脱氧多肽，其中R表示多羟脯氨酸的羟基，R表示 氢原子用于脱氧脱氧蛋白，通过培养链霉菌 MK498-98F14菌株。 多氧蛋白和脱氧多肽蛋白是具有诱导人胰腺癌细胞AsPC-1细胞凋亡的生理活性物质。
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7.发明公开COMPOSITIONS FOR TREATING OR PREVENTING MALARIA AND METHOD OF TREATING MALARIA 有权混合物用于治疗疟疾的治疗或预防疟疾和方法
公开(公告)号：EP1295881A1
公开(公告)日：2003-03-26
申请号：EP01925951.4
申请日：2001-04-26
发明人： TAKEUCHI, Tomio, New Fuji Mansion 701 , WATAYA, Yusuke , IINUMA, Munekazu , KIM, Hye-Sook , WATABE, Hiroomi , NAGANAWA, Hiroshi , TAKAHASHI, Yoshikazu
IPC分类号： C07D407/14 , A61K31/351 , A61P33/06
CPC分类号： C07D407/14 , A61K31/351 , Y02A50/411
摘要： An antibiotic SF2487 substance having the formula (I)
or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an antimalarial drug.摘要翻译： 具有式（I）
或其盐的抗生素SF2487物质其具有抗疟疾针对疟疾寄生虫的增殖活性，因此是作为抗疟疾药物是有用的。 -
8.发明公开ANTIBIOTICS TRIPROPEPTINS AND PROCESS FOR PRODUCING THE SAME 有权抗生素TRIPROPEPTINE VERFAHREN IHRER HERSTELLUNG
公开(公告)号：EP1285928A1
公开(公告)日：2003-02-26
申请号：EP01917554.6
申请日：2001-03-28
发明人： TAKEUCHI, Tomio, New Fuji Mansion 701 , HASHIZUME, Hideki , IGARASHI, Masayuki , NAGANAWA, Hiroshi , HAMADA, Masa
摘要： By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general formula (I):
wherein R is 7-methyl-octyl group, 8-methyl-nonyl group, 9-methyl-dodecyl group, 10-methyl-undecyl group or 11-methyl-dodecyl group, is obtained as antibiotics having excellent antibacterial activities against bacteria and having a novel molecular structure. These tripropeptins each have an excellent antibacterial activity against various bacteria and drug-resistant strains thereof, such as methicillin-resistant strains and vancomycin-resistant strains.摘要翻译： 通过培养溶菌杆菌 BMK333-48F3（FERM BP-7477的保藏号），抗生素，三丙胰蛋白酶Z，三聚肽A，三聚蛋白B，三肽肽C或由通式（I）表示的三聚肽D：其中R为7-甲基 - 辛基 得到作为对细菌具有优异的抗细菌活性并具有新的分子结构的抗生素的8-甲基壬基，9-甲基 - 十二烷基，10-甲基 - 十一烷基或11-甲基 - 十二烷基。 这些三柔比星各自对各种细菌和耐药菌株具有优异的抗菌活性，如耐甲氧西林株和万古霉素抗性菌株。
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9.发明公开
公开(公告)号：EP0423358A1
公开(公告)日：1991-04-24
申请号：EP90905686.3
申请日：1990-04-13
发明人： TAKEUCHI, Tomio , AOYAGI, Takaaki , HAMADA, Masa , NAGANAWA, Hiroshi , MURAOKA, Yasuhiko , OGAWA, Keiji , NAGAI, Machiko,Syare Gakugeidai Kawabe 2-207 , TSUDA, Makoto, Nippon Kayaku Kabushiki Kaisha
CPC分类号： C07C229/22 , A61K38/00 , C07C271/22 , C07K5/0202 , C07K7/02
摘要： Postostatin, a new physiologically active substance represented by (I), can be isolated from the culture medium of an actinomycete belonging to the genus Streptomyces. It is a peptide compound having a new structure wherein a keto group is present in the peptide chain and it has a potent endopeptidase inhibitory activity. A postostatin-related compound having a keto group in the peptide chain can he synthesized chemically and this compound has a similar endopeptidase inhibitory activity.
摘要翻译： 由（I）表示的新的生理活性物质Postostatin可以从属于链霉菌属的放线菌的培养基中分离出来。 它是具有新结构的肽化合物，其中酮基存在于肽链中，并且其具有有效的内肽酶抑制活性。 肽链中具有酮基的抑制素相关化合物可以化学合成，该化合物具有相似的内肽酶抑制活性。
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