发明公开
- 专利标题： SULFONAMIDES AS CELL ADHESION INHIBITORS
- 专利标题（中）： 磺酰胺作为细胞粘附抑制剂
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申请号： EP98924989.1申请日： 1998-05-29
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公开(公告)号： EP0998282A1公开(公告)日： 2000-05-10
- 发明人: DURETTE, Philippe, L. , HAGMANN, William, K. , MacCOSS, Malcolm , MILLS, Sander, G. , MUMFORD, Richard, A.
- 申请人： Merck & Co., Inc. (a New Jersey corp.)
- 申请人地址： 126 East Lincoln Avenue Rahway, N.J. 07065 US
- 专利权人： Merck & Co., Inc. (a New Jersey corp.)
- 当前专利权人： Merck & Co., Inc. (a New Jersey corp.)
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, N.J. 07065 US
- 代理机构： Hiscock, Ian James
- 优先权： US47954P 19970529; GB9714335 19970707; US66787P 19971125; GB9800684 19980114
- 国际公布： WO9853818 19981203
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; A61K31/415 ; A61K31/425 ; A61K31/505 ; C07C255/03 ; C07D207/08 ; C07D217/18 ; C07D231/04 ; C07D263/04 ; C07D277/04 ; C07D285/12 ; C07D295/023 ; C07D413/10 ; C07D417/10
摘要：
Compounds of formula (I) are antagonists of VLA-4 and/or α4-β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
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