发明公开
EP1000047A1 1-(N-PHENYLAMINOALKYL)-PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING
失效
2-苯基取代的1-(N- PHENYLAMINOALKYL)哌嗪衍生物
- 专利标题: 1-(N-PHENYLAMINOALKYL)-PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING
- 专利标题(中): 2-苯基取代的1-(N- PHENYLAMINOALKYL)哌嗪衍生物
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申请号: EP98943815.5申请日: 1998-07-31
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公开(公告)号: EP1000047A1公开(公告)日: 2000-05-17
- 发明人: LEONARDI, Amedeo , MOTTA, Gianni , RIVA, Carlo , TESTA, Rodolfo
- 申请人: RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY , RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 申请人地址: Piazza Boffalora 4 6830 Chiasso CH
- 专利权人: RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY,RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 当前专利权人: RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY,RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 当前专利权人地址: Piazza Boffalora 4 6830 Chiasso CH
- 代理机构: McKelvey, Ian Edward
- 优先权: ITMI971864 19970801
- 国际公布: WO9906384 19990211
- 主分类号: C07D295/12
- IPC分类号: C07D295/12 ; C07D307/68 ; C07D295/22 ; C07D333/38 ; C07D213/81 ; C07D213/82 ; C07D241/24 ; C07D209/08 ; A61K31/495
摘要:
1-(N-phenylaminoalkyl)-piperazine derivatives of formula (I), (R = H, alkyl-CO, cycloalkyl-CO, substituted cycloalkyl-CO or monocyclic heteroaryl-CO; R1 = H or lower alkyl; R2 = halogen, alkoxy, phenoxy, NO2, CN, acyl, NH2, NH(acyl), alkyl-SO2NH, alkoxycarbonyl, NH2CO, (alkyl)NHCO, (alkyl)2NCO, (acyl)NHCO, CF3 or polyfluoroalkoxy; B = benzyl or mono- or bicyclic aryl or heteroaryl, all optionally substituted) bind to 5HT1A receptors and are useful for the treatment of neuromuscular dysfunctions of the lower urinary tract. The use of these compounds for the preparation of a medicament for this treatment is claimed, and some of the compounds (with restricted B values) are claimed per se.
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