发明公开
EP1015492A2 ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS
审中-公开
ASTMA相关因子为靶特应性过敏AS ASTMA和相关疾病的治疗
- 专利标题： ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS
- 专利标题（中）： ASTMA相关因子为靶特应性过敏AS ASTMA和相关疾病的治疗
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申请号： EP98948370.6申请日： 1998-09-18
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公开(公告)号： EP1015492A2公开(公告)日： 2000-07-05
- 发明人: RENAULD, Jean-Christophe , LOUAHED, Jamila , GRASSO, Luigi , LEVITT, Roy , NICOLAIDES, Nicholas
- 申请人： MAGAININ PHARMACEUTICALS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH
- 申请人地址： 5110 Campus Drive Plymouth MeetingPA 19462 US
- 专利权人： MAGAININ PHARMACEUTICALS INC.,LUDWIG INSTITUTE FOR CANCER RESEARCH
- 当前专利权人： MAGAININ PHARMACEUTICALS INC.,LUDWIG INSTITUTE FOR CANCER RESEARCH
- 当前专利权人地址： 5110 Campus Drive Plymouth MeetingPA 19462 US
- 代理机构： Doireau, Marc
- 优先权： US59509P 19970919
- 国际公布： WO9914242 19990325
- 主分类号： C07K14/82
- IPC分类号： C07K14/82 ; C12N15/12 ; C12N15/11 ; C12Q1/68 ; G01N33/53 ; C07K16/32 ; A61K38/17
摘要：
A new gene in the Ras family that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and certain lymphomas or leukemias. A method for the identification and use of small molecule inhibitors of Ras to treat these disorders. A method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders and certain lymphomas and leukemias by measuring the level of Ras in biologic samples using antibody specific for the Ras protein.
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