发明公开
EP1017681A1 DERIVES D'HYDRAZONO-BENZAZULENE, COMPOSITIONS PHARMACEUTIQUES ET INTERMEDIAIRES
有权
肼基benzazulene衍生物,药物组合物和中间产品
- 专利标题: DERIVES D'HYDRAZONO-BENZAZULENE, COMPOSITIONS PHARMACEUTIQUES ET INTERMEDIAIRES
- 专利标题(英): Hydrazono-benzazulene derivatives, pharmaceutical compositions and intermediates
- 专利标题(中): 肼基benzazulene衍生物,药物组合物和中间产品
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申请号: EP98945363.4申请日: 1998-09-23
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公开(公告)号: EP1017681A1公开(公告)日: 2000-07-12
- 发明人: CARNIATO, Denis , GADEK, Thomas, R. , GOUBET, François , GOURVEST, Jean-François , KNOLLE, Jochen , MCDOWELL, Robert , SCHEUNEMANN, Karl-Heinz
- 申请人: HOECHST MARION ROUSSEL , GENENTECH, INC.
- 申请人地址: 1, Terrasse Bellini 92800 Puteaux FR
- 专利权人: HOECHST MARION ROUSSEL,GENENTECH, INC.
- 当前专利权人: HOECHST MARION ROUSSEL,GENENTECH, INC.
- 当前专利权人地址: 1, Terrasse Bellini 92800 Puteaux FR
- 代理机构: Vieillefosse, Jean-Claude
- 优先权: FR9711859 19970924
- 国际公布: WO9915507 19990401
- 主分类号: C07D233/52
- IPC分类号: C07D233/52 ; A61K31/415 ; C07C49/747 ; C07C333/04 ; C07C323/22
摘要:
The invention concerns products of formula (I) in which R1 represents S(O)X-[A]-[B]-COR6, x being equal to 0, 1 or 2; [A]- representing a bivalent radical derived from an aliphatic hydrocarbon, linear or branched, saturated or unsaturated, comprising 1 to 12 carbon atoms; [B] representing a phenyl radical, a CH(Z) radical or a single bond; G represents, either a radical of formula (G1) in which (Het') is a heterocycle of general formula (a), in which (H) forms, with the structural unit N=C-NH-, the residue of an aromatic or non-aromatic heterocycle, monocyclic or bicyclic, saturated or unsaturated, comprising 1 to 9 carbon atoms and 2 to 5 heteroatoms selected among oxygen, nitrogen or sulphur atoms, or a NRaRb radical (radical G2), or a (Het) radical (radical G3), or a -NRh-C(=X)-NHRc radical (radical G4), in which X is a sulphur, oxygen or NH atom, or a -NRh-SO2Rc radical (radical G5), and their additive salts with acids, bases and esters, the method for preparing them and the intermediates of said method, their application as medicines and the pharmaceutical compositions containing them.
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