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1.发明公开DERIVES D'HYDRAZONO-BENZAZULENE, COMPOSITIONS PHARMACEUTIQUES ET INTERMEDIAIRES 有权肼基benzazulene衍生物，药物组合物和中间产品
公开(公告)号：EP1017681A1
公开(公告)日：2000-07-12
申请号：EP98945363.4
申请日：1998-09-23
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOUBET, François , GOURVEST, Jean-François , KNOLLE, Jochen , MCDOWELL, Robert , SCHEUNEMANN, Karl-Heinz
IPC分类号： C07D233/52 , A61K31/415 , C07C49/747 , C07C333/04 , C07C323/22
CPC分类号： C07C333/04 , C07C49/747 , C07C323/22 , C07D233/52
摘要： The invention concerns products of formula (I) in which R1 represents S(O)X-[A]-[B]-COR6, x being equal to 0, 1 or 2; [A]- representing a bivalent radical derived from an aliphatic hydrocarbon, linear or branched, saturated or unsaturated, comprising 1 to 12 carbon atoms; [B] representing a phenyl radical, a CH(Z) radical or a single bond; G represents, either a radical of formula (G1) in which (Het') is a heterocycle of general formula (a), in which (H) forms, with the structural unit N=C-NH-, the residue of an aromatic or non-aromatic heterocycle, monocyclic or bicyclic, saturated or unsaturated, comprising 1 to 9 carbon atoms and 2 to 5 heteroatoms selected among oxygen, nitrogen or sulphur atoms, or a NRaRb radical (radical G2), or a (Het) radical (radical G3), or a -NRh-C(=X)-NHRc radical (radical G4), in which X is a sulphur, oxygen or NH atom, or a -NRh-SO2Rc radical (radical G5), and their additive salts with acids, bases and esters, the method for preparing them and the intermediates of said method, their application as medicines and the pharmaceutical compositions containing them.
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公开(公告)号：EP0869946A1
公开(公告)日：1998-10-14
申请号：EP96942431.0
申请日：1996-12-19
CPC分类号： C07D233/78
摘要： Products of formula (I), wherein R1 and R2 are particularly cyano and trifluoromethyl, R3 is particularly alkyl, alkenyl or alkynyl optionally substituted by nitrooxy or carbonyloxy, R4 and R5 are particularly methyl optionally substituted by fluorine, and X and Y are particularly oxygen, as well as salts and isomers thereof, are disclosed.
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3.发明公开NOUVELLES PHENYLIMIDAZOLIDINES FLUOREES OU HYDROXYLEES AYANT UNE ACTIVITE ANTI-ANDROGENIQUE, LEUR PROCEDE DE PREPARATION, INTERMEDIAIRES OBTENUS ET COMPOSITIONS PHARMACEUTIQUES 失效新的氟化或具有抗ANDROGENIER活性羟基化苯基咪唑，工艺FOR THEIR接受品及医药组成之间
公开(公告)号：EP0862559A1
公开(公告)日：1998-09-09
申请号：EP96939961.0
申请日：1996-11-21
CPC分类号： C07D235/02 , A61K31/4166 , C07D233/76
摘要： Products of formula (I), wherein R1 and R2 are particularly cyano and trifluoromethyl, R3 is particularly alkyl, alkenyl or alkynyl, optionally substituted by one or more of halogen, cyano or hydroxyl, R4 and R5 either are particularly methyl optionally substituted by fluorine or form particularly a cyclohexyl radical, and X and Y are particularly oxygen, as well as salts and isomers thereof, are disclosed.
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4.发明授权DERIVES D'HYDRAZONO-BENZAZULENE, COMPOSITIONS PHARMACEUTIQUES ET INTERMEDIAIRES 有权肼基benzazulene衍生物，药物组合物和中间产品
公开(公告)号：EP1017681B1
公开(公告)日：2003-04-09
申请号：EP98945363.4
申请日：1998-09-23
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOUBET, François , GOURVEST, Jean-François , KNOLLE, Jochen , MCDOWELL, Robert , SCHEUNEMANN, Karl-Heinz
IPC分类号： C07D233/52 , A61K31/415 , C07C49/747 , C07C333/04 , C07C323/22
CPC分类号： C07C333/04 , C07C49/747 , C07C323/22 , C07D233/52
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