发明公开
- 专利标题： AMORPHOUS PAROXETINE COMPOSITION
- 专利标题（中）： 编制非晶帕罗西汀
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申请号： EP98951989.7申请日： 1998-09-30
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公开(公告)号： EP1019053A1公开(公告)日： 2000-07-19
- 发明人: RONSEN, Bruce , EL-RASHIDY, Ragab
- 申请人： PENTECH PHARMACEUTICALS, INC.
- 申请人地址： Suite 257,1110 Lake Cook Road Buffalo Grove, IL 60089 US
- 专利权人： PENTECH PHARMACEUTICALS, INC.
- 当前专利权人： PENTECH PHARMACEUTICALS, INC.
- 当前专利权人地址： Suite 257,1110 Lake Cook Road Buffalo Grove, IL 60089 US
- 代理机构： Vossius, Volker, Dr.
- 优先权： US940058 19970930
- 国际公布： WO9916440 19990408
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K9/00 ; A61K9/16 ; A61K9/20
摘要：
A free-flowing, amorphous paroxetine hydrochloride composition suitable as a therapeutic agent for premature ejaculation can be prepared by dissolving paroxetine free base in a hydrochloric acid-ethanol solution followed by drying. The present compositions comprise amorphous paroxetine hydrochloride and at least one hydroxyl-bearing compound. In one preferred embodiment, the hydroxyl-bearing compound is ethanol and the amount of ethanol present in the amorphous product is in the range of 1 to 4 weight percent based on paroxetine hydrochloride. The amorphous product is stable and substantially non-hygroscopic.
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