公开(公告)号：EP1303275A2

公开(公告)日：2003-04-23

申请号：EP01959253.4

申请日：2001-07-25

申请人： Pentech Pharmaceuticals, Inc.

发明人： RONSEN, Bruce ,  KOTA, Venkata, R. ,  SADHALE, Yogesh, D.

IPC分类号： A61K31/4525 ,  A61K9/16 ,  A61K9/20 ,  A61K9/08

CPC分类号： A61K9/2013 ,  A61K9/08 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/2027 ,  A61K31/4525 ,  A61K47/12

摘要： Methods for preparing a wet granule formulation of paroxetine hydrochloride are disclosed. The formulations are suitable for tabletting and capsulation.

摘要翻译： 公开了制备帕罗西汀盐酸盐的湿颗粒制剂的方法。 该制剂适用于压片和封装。

公开(公告)号：EP1017371A4

公开(公告)日：2000-07-12

申请号：EP98919989

申请日：1998-04-29

申请人： PENTECH PHARMACEUTICALS INC

发明人： EL-RASHIDY RAGAB ,  RONSEN BRUCE ,  HASSAN EMAD ELDIN

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K31/137 ,  A61K31/277 ,  A61K31/473 ,  A61K31/485 ,  A61K31/5377 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/42 ,  A61P15/10

CPC分类号： A61K31/5377 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/137 ,  A61K31/277 ,  A61K31/473 ,  A61K31/485

摘要： A composition providing a relatively slow release of water-soluble drugs, such as apomorphine, for delivery via the sublingual or buccal routes.

公开(公告)号：EP0800364A4

公开(公告)日：1998-04-01

申请号：EP95944522

申请日：1995-12-22

申请人： PENTECH PHARMACEUTICALS INC

发明人： DURIF FRANCK ,  EL-RASHIDY RAGAB

IPC分类号： A61K9/70 ,  A61K31/485 ,  A61K47/32 ,  A61K47/38 ,  A61F13/00

CPC分类号： A61K9/7069 ,  A61K9/0014 ,  A61K9/7092 ,  A61K31/485 ,  A61K47/32 ,  A61K47/38 ,  Y10S514/944

摘要： Dosage forms for the transdermal administration of apomorphine are described. The dosage forms are water-soluble gel compositions that contain apomorphine, optionally together with a permeation enhancer, or transdermal patches.

公开(公告)号：EP0800364A1

公开(公告)日：1997-10-15

申请号：EP95944522.0

申请日：1995-12-22

申请人： PENTECH PHARMACEUTICALS, INC.

发明人： DURIF, Franck ,  EL-RASHIDY, Ragab

IPC分类号： A61K9 ,  A61K31 ,  A61K47

CPC分类号： A61K9/7069 ,  A61K9/0014 ,  A61K9/7092 ,  A61K31/485 ,  A61K47/32 ,  A61K47/38 ,  Y10S514/944

摘要： Dosage forms for the transdermal administration of apomorphine are described. The dosage forms are water-soluble gel compositions that contain apomorphine, optionally together with a permeation enhancer, or transdermal patches (10), which comprise a matrix containing apomorphine (14), an occlusive backing layer (12) and a release liner (16).

公开(公告)号：EP0758895A1

公开(公告)日：1997-02-26

申请号：EP95916467.0

申请日：1995-04-21

申请人： PENTECH PHARMACEUTICALS, INC. ,  QUEEN'S UNIVERSITY AT KINGSTON

发明人： EL-RASHIDY, Ragab ,  HEATON, Jeremy P.W. ,  MORALES, Alvaro ,  ADAMS, Michael A.

IPC分类号： C07D221 ,  A61K9 ,  A61K31 ,  A61K47 ,  A61K49 ,  A61P15

CPC分类号： A61K31/00 ,  A61K9/0056 ,  A61K9/006 ,  A61K31/473 ,  A61K31/485 ,  A61K49/0004

摘要： Pyschogenic impotence or erectile dysfunction can be identified in psychogenic male patients and can be ameliorated, without substantial undesirable side effects, by sublingual administration of apomorphine dosage forms that contain about 2.5 to about 10 milligrams of apomorphine and dissolve within a time period of about 2 to about 5 minutes.

公开(公告)号：EP1140832A4

公开(公告)日：2004-11-03

申请号：EP99966475

申请日：1999-12-17

申请人： PENTECH PHARMACEUTICALS INC

发明人： RONSEN BRUCE ,  UPADHYAYA SUBHASH P

IPC分类号： C07C253/30 ,  C07C255/41 ,  C07D211/78 ,  C07D211/22

CPC分类号： C07C255/41 ,  C07B2200/07 ,  C07D211/78

摘要： A process for the synthesis of arylpiperidine carbinol intermediates and derivatives is disclosed. A preferred process embodiment provides the synthesis of intermediate compounds of structural formula (I) and structural formula (II), where X is halogen, C1-C10 alkyl, C1-C10 alkoxy, C1-C10 haloalkyl, hydroxy, or hydrogen; and R2 and R3 each is C1-C4 alkyl and R2 and R3 are the same. The compound of structural formula (I) is made by condensing a corresponding cinnamonitrile with a corresponding diester malonate. The compound of structural formula (II) in the (±)-trans configuration is obtained by hydrogenating the compound of structural formula (I). The compounds of structural formula (I) and structural formula (II) are useful chemical intermediates for synthesizing 4-arylpiperidine-3-carbinols and their derivatives in (-)-trans configuration.

公开(公告)号：EP1448194A1

公开(公告)日：2004-08-25

申请号：EP02773812.9

申请日：2002-10-21

申请人： Pentech Pharmaceuticals, Inc.

发明人： EL-RASHIDY, Ragab ,  RONSEN, Bruce

IPC分类号： A61K31/44

CPC分类号： A61K9/0056 ,  A61K31/00 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/472 ,  A61K31/473 ,  A61K31/485 ,  A61K31/506 ,  A61K49/0004

摘要： Impotence can be ameliorated without substantial undesirable side effects by nasal administration of apomorphine, optionally with an antiemetic agent present in an amount sufficient to substantially reduce nausea symptons that may be associated with the use of apomorphine.

公开(公告)号：EP1017371B1

公开(公告)日：2003-07-02

申请号：EP98919989.8

申请日：1998-04-29

申请人： Pentech Pharmaceuticals, Inc.

发明人： EL-RASHIDY, Ragab ,  RONSEN, Bruce ,  HASSAN, Emad, Eldin

IPC分类号： A61K9/22

CPC分类号： A61K31/5377 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/137 ,  A61K31/277 ,  A61K31/473 ,  A61K31/485

摘要： A composition providing a relatively slow release of water-soluble drugs, such as apomorphine, for delivery via the sublingual or buccal routes.

公开(公告)号：EP0800364B1

公开(公告)日：2003-03-19

申请号：EP95944522.2

申请日：1995-12-22

申请人： PENTECH PHARMACEUTICALS, INC.

发明人： DURIF, Franck ,  EL-RASHIDY, Ragab

IPC分类号： A61K31/485 ,  A61K9/70

CPC分类号： A61K9/7069 ,  A61K9/0014 ,  A61K9/7092 ,  A61K31/485 ,  A61K47/32 ,  A61K47/38 ,  Y10S514/944

公开(公告)号：EP1173178A4

公开(公告)日：2002-09-04

申请号：EP00916324

申请日：2000-03-14

申请人： PENTECH PHARMACEUTICALS INC

发明人： EL-RASHIDY RAGAB

IPC分类号： A61K47/40 ,  A61K31/201 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/473 ,  A61K31/505 ,  A61K31/517 ,  A61K31/522 ,  A61K31/568 ,  A61K31/5685 ,  A61P15/10 ,  A61P43/00 ,  A61K31/44

CPC分类号： A61K31/505 ,  A61K31/47 ,  A61K2300/00