发明公开
EP1044209A1 PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A USING 9-HYDROXY ERYTHROMYCIN DERIVATIVES
有权
用9-羟基红霉素衍生物制备6-O-甲基红霉素A的方法
- 专利标题： PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A USING 9-HYDROXY ERYTHROMYCIN DERIVATIVES
- 专利标题（中）： 用9-羟基红霉素衍生物制备6-O-甲基红霉素A的方法
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申请号： EP98959481.7申请日： 1998-11-17
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公开(公告)号： EP1044209A1公开(公告)日： 2000-10-18
- 发明人: KU, Yi-Yin , RILEY, David, A. , LEE, Elaine, C. , TIEN, Jien-Heh, J.
- 申请人： Abbott Laboratories
- 申请人地址： Chad 0377/AP6D-2,100 Abbott Park Road Abbott Park,Illinois 60064-3500 US
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： Chad 0377/AP6D-2,100 Abbott Park Road Abbott Park,Illinois 60064-3500 US
- 代理机构： Modiano, Guido, Dr.-Ing.
- 优先权： US991648 19971216
- 国际公布： WO9931114 19990624
- 主分类号： C07H17/08
- IPC分类号： C07H17/08
摘要：
The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4'-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.
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