1,2-Dihydro-2-oxoquinoline derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein Ar represents pyridyl or group represented by general formula (II) (wherein X?3 and X4¿ are the same or different and each represents hydrogen, halogeno, C¿1-5? alkyl, C1-5 alkoxy, hydroxy, or trifluoromethyl); Y represents nitrogen, CH, or C(OH); R?1 and R2¿ are the same or different and each represents hydrogen, C¿1-10? alkyl, C3-15 alkoxyalkyl, or C3-15 alkylaminoalkyl or R?1 and R2¿ form a cycloamino group together with the adjacent nitrogen atom; X?1 and X2¿ are the same or different and each represents hydrogen, C¿1-5? alkyl, C1-5 alkoxy, or halogeno or X?1 and X2¿ together represent alkylenedioxy; and n is an integer of 1 to 3.