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    CARBAMOYL TETRAHYDROPYRIDINE DERIVATIVES
    4.
    发明公开
    CARBAMOYL TETRAHYDROPYRIDINE DERIVATIVES 有权
    氨基甲酰四氢吡啶衍生物

    公开(公告)号：EP1176146A1

    公开(公告)日：2002-01-30

    申请号：EP00907999.7

    申请日：2000-03-10

    申请人： TAISHO PHARMACEUTICAL CO., LTD

    发明人： NAKAZATO, Atsuro ,  OKUBO, Taketoshi ,  KUMAGAI, Toshihito ,  TOMISAWA, Kazuyuki

    IPC分类号： C07D473/34 ,  C07D487/04 ,  C07D211/78 ,  C07D207/34 ,  A61K31/52 ,  A61K31/519 ,  A61P43/00 ,  A61P25/24 ,  A61P25/22 ,  A61P25/28 ,  A61P25/16 ,  A61P25/30 ,  A61P25/08 ,  A61P1/00 ,  A61P7/10 ,  A61P9/10 ,  A61P9/12 ,  A61P17/02 ,  A61P29/00 ,  A61P37/02

    CPC分类号： A61K31/519 ,  C07D473/00 ,  C07D487/04

    摘要： Carbamoyl tetrahydropyridine derivatives represented by the formula:
    [in the formula, R 1 and R 2 are identical or different, and each represents a hydrogen atom, a C 1 -C 5 alkyl group, or the like; Y 1 -Y 2 represents (R 4 )C=C(R 5 ), (R 6 )C=N, N=N, (R 7 )N-CO, or N=C(R 8 ); X 1 , X 2 , and X 3 are identical or different, and each represents a hydrogen atom, a halogen atom, or the like; R 3 , R 4 , R 5 , and R 6 are identical or different, and each represents a hydrogen atom or an alkyl group; R 7 represents a hydrogen atom, a C 1 -C 5 alkyl group, or the like; and R 8 represents a hydrogen atom or a carbamoyl group] or a pharmaceutically acceptable salt thereof, and intermediates for the preparation thereof are provided.
    The derivatives described above are effective for diseases which are believed to involve CRF.

    摘要翻译： 由下式表示的氨基甲酰基四氢吡啶衍生物[式中，R1和R2相同或不同，且各自表示氢原子，C1-C5烷基等; Y1-Y2表示（R4）C = C（R5），（R6）C = N，N = N，（R7）N-CO或N = C（R8）。 X 1，X 2和X 3相同或不同，并且各自表示氢原子，卤素原子等; R3，R4，R5和R6相同或不同，并且各自表示氢原子或烷基; R7代表氢原子，C1-C5烷基等; 并且R 8表示氢原子或氨基甲酰基]或其药学上可接受的盐，以及用于其制备的中间体。 上述衍生物对于认为涉及CRF的疾病是有效的。

    1,2-DIHYDRO-2-OXOQUINOLINE DERIVATIVES
    5.
    发明公开
    1,2-DIHYDRO-2-OXOQUINOLINE DERIVATIVES 有权
    1,2-二氢-2- OXOCHINOLIN衍

    公开(公告)号：EP1048655A1

    公开(公告)日：2000-11-02

    申请号：EP98957145.0

    申请日：1998-12-03

    申请人： TAISHO PHARMACEUTICAL CO., LTD ,  Nihon Nohyaku Co., Ltd.

    发明人： NAKAZATO, Atsuro ,  OKUBO, Taketoshi ,  KUMAGAI, Toshihito ,  CHAKI, Shigeyuki ,  TOMISAWA, Kazuyuki ,  NAGAMINE, Masashi ,  GOTOH, Makoto ,  YOSHIDA, Masanori

    IPC分类号： C07D215/54 ,  C07D215/56 ,  C07D241/44 ,  C07D491/056 ,  A61K31/47 ,  A61K31/495

    CPC分类号： C07D401/06 ,  C07D215/54 ,  C07D241/44

    摘要： A 1,2-dihydro-2-oxoquinoline derivative represented by the formula:
    wherein Ar is a pyridyl group or a group represented by the formula:
    (wherein X 3 and X 4 are the same or different, and are each a hydrogen atom, a halogen atom, a C 1-5 alkyl group, a C 1-5 alkoxy group, a hydroxyl group or a trifluoromethyl group), Y is a nitrogen atom, CH or C(OH), R 1 and R 2 are the same or different, and are each a hydrogen atom, a C 1-10 alkyl group, a C 3-15 alkoxyalkyl group or a C 3-15 alkylaminoalkyl group, or R 1 and R 2 taken together with the nitrogen atom to which they are attached form a cyclic amino group, X 1 and X 2 are the same or different, and are each a hydrogen atom, a C 1-5 alkyl group, a C 1-5 alkoxy group or a halogen atom, or X 1 and X 2 taken together form an alkylenedioxy group, and n is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 由下式表示的1,2-二氢-2-氧代喹啉衍生物：其中Ar为吡啶基或由下式表示的基团：其中X 3和X 4相同 或不同，并且各自为氢原子，卤素原子，C 1-5烷基，C 1-5烷氧基，羟基或三氟甲基），Y为氮原子，CH或C（OH） R 1和R 2相同或不同，各自为氢原子，C 1-10烷基，C 3-15烷氧基烷基或C 3-15烷基氨基烷基，或R 1和R 2 与它们所连接的氮原子一起形成环状氨基，X 1和X 2相同或不同，分别为氢原子，C 1-5烷基， C 1-5烷氧基或卤原子，或X 1和X 2一起形成亚烷基二氧基，n为1〜3的整数。 或其药学上可接受的盐。