发明公开
- 专利标题： Dopamine transporter imaging agents
- 专利标题（中）： Bild erzeugende SubstanzenfürDopamintransporter
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申请号： EP99121068.3申请日： 1999-10-21
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公开(公告)号： EP1051980A2公开(公告)日： 2000-11-15
- 发明人: Meltzer, Peter C. , Blundell, Paul , Madras, Bertha K. , Fischman, Alan J. , Jones, Alan G. , Mahmood, Ashfaq
- 申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , ORGANIX, INC. , THE GENERAL HOSPITAL CORPORATION
- 申请人地址： University Place, 124 Mount Auburn Cambridge, Massachusetts 02138-5701 US
- 专利权人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE,ORGANIX, INC.,THE GENERAL HOSPITAL CORPORATION
- 当前专利权人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE,ORGANIX, INC.,THE GENERAL HOSPITAL CORPORATION
- 当前专利权人地址： University Place, 124 Mount Auburn Cambridge, Massachusetts 02138-5701 US
- 代理机构： Prüfer, Lutz H., Dipl.-Phys.
- 优先权： US133761P 19990512
- 主分类号： A61K51/04
- IPC分类号： A61K51/04
摘要：
Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
公开/授权文献
- EP1051980B1 Dopamine transporter imaging agents 公开/授权日：2010-12-15
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