发明公开
EP1060160A2 DISUBSTITUTED LAVENDUSTIN A ANALOGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ANALOGS
审中-公开
脱氧核糖核酸酶ANALOGEN UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
- 专利标题： DISUBSTITUTED LAVENDUSTIN A ANALOGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ANALOGS
- 专利标题（中）： 脱氧核糖核酸酶ANALOGEN UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
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申请号： EP99910987.9申请日： 1999-02-24
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公开(公告)号： EP1060160A2公开(公告)日： 2000-12-20
- 发明人: NARAYANAN, Venkatachala, L. , SAUSVILLE, Edward, A. , KAUR, Gurmeet , VARMA, Ravi, K.
- 申请人： THE UNITED STATES GOVERNMENTas represented byTHE DEPARTMENTOF HEALTH AND HUMAN SERVICES
- 申请人地址： Office of Technology Transfer,Suite 325,6011 Executive Boulevard Rockville, MD 20852-3804 US
- 专利权人： THE UNITED STATES GOVERNMENTas represented byTHE DEPARTMENTOF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE UNITED STATES GOVERNMENTas represented byTHE DEPARTMENTOF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： Office of Technology Transfer,Suite 325,6011 Executive Boulevard Rockville, MD 20852-3804 US
- 代理机构： Gowshall, Jonathan Vallance
- 优先权： US76330P 19980227
- 国际公布： WO9943636 19990902
- 主分类号： C07C229/60
- IPC分类号： C07C229/60 ; A61K31/195 ; C07C69/94 ; C07C69/95 ; C07C65/19 ; C07C229/64 ; C07C237/30 ; C07C225/28 ; C07C225/22 ; C07C215/68 ; C07F9/38
摘要：
Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the present invention, without limitation, satisfy either Formula (1) or Formula (2). Currently preferred compounds, based on in vivo biological activity, are 4'-adamantylbenzoate-1'-N-1,4-dihydroxybenzylamine and 4'-adamantylmethylbenzoate-1'-N-1,4-dihydroxybenzylamine. The present invention also provides pharmaceutical compositions comprising effective amounts of disubstituted lavendustin A analogs. Such compositions also may comprise other active ingredients, other materials conventionally used in the formulation of pharmaceutical compositions, and mixtures thereof. The compounds and compositions of the present invention can be used for treating subjects to, for example, inhibit the proliferation of living cells in the treatment of proliferative diseases.
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