发明公开
EP1067940A1 ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS
审中-公开
支气管哮喘相关因素，如特应性目标过敏的治疗包括哮喘和相关疾病
- 专利标题： ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS
- 专利标题（中）： 支气管哮喘相关因素，如特应性目标过敏的治疗包括哮喘和相关疾病
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申请号： EP99911092.7申请日： 1999-03-03
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公开(公告)号： EP1067940A1公开(公告)日： 2001-01-17
- 发明人: HOLROYD, Kenneth, J. , LEVITT, Roy, C. , MALOY, W., Lee , LOUAHED, Jamila , McLANE, Mike , NICOLAIDES, Nicholas, C. , ZHOU, Yuhong , DONG, Qu
- 申请人： MAGAININ PHARMACEUTICALS INC.
- 申请人地址： 5110 Campus Drive Plymouth MeetingPA 19462 US
- 专利权人： MAGAININ PHARMACEUTICALS INC.
- 当前专利权人： MAGAININ PHARMACEUTICALS INC.
- 当前专利权人地址： 5110 Campus Drive Plymouth MeetingPA 19462 US
- 代理机构： Goulard, Sophie
- 优先权： US76815P 19980303
- 国际公布： WO9944620 19990910
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K39/395 ; C07H21/04 ; G01N33/53
摘要：
A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.
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