专利检索 ap:("MAGAININ PHARMACEUTICALS INC.") AND inv:"McLANE, Mike" 第 1 页

1.

发明公开
ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开
标题翻译：支气管哮喘相关因素，如特应性目标过敏的治疗包括哮喘和相关疾病

公开(公告)号：EP1067940A1

公开(公告)日：2001-01-17

申请号：EP99911092.7

申请日：1999-03-03

申请人： MAGAININ PHARMACEUTICALS INC.

发明人： HOLROYD, Kenneth, J. , LEVITT, Roy, C. , MALOY, W., Lee , LOUAHED, Jamila , McLANE, Mike , NICOLAIDES, Nicholas, C. , ZHOU, Yuhong , DONG, Qu

IPC分类号： A61K31/70 , A61K39/395 , C07H21/04 , G01N33/53

CPC分类号： C07K14/705 , A61K38/00 , G01N33/6872 , G01N2500/00 , Y10S977/914 , Y10S977/927

摘要： A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.