发明公开
EP1070054A1 AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS
审中-公开
阿明化合物,它们的生产及其作为生长抑素受体拮抗剂或激动剂
- 专利标题: AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS
- 专利标题(中): 阿明化合物,它们的生产及其作为生长抑素受体拮抗剂或激动剂
-
申请号: EP99945683.3申请日: 1999-04-08
-
公开(公告)号: EP1070054A1公开(公告)日: 2001-01-24
- 发明人: SUZUKI, Nobuhiro , KATO, Kaneyoshi , TAKEKAWA, Shiro , TERAUCHI, Jun , ENDO, Satoshi
- 申请人: Takeda Chemical Industries, Ltd.
- 申请人地址: 1-1 Doshomachi 4-chome,Chuo-ku Osaka-shi,Osaka 541-0045 JP
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: 1-1 Doshomachi 4-chome,Chuo-ku Osaka-shi,Osaka 541-0045 JP
- 代理机构: Caffin, Lee
- 优先权: JP9642298 19980408; JP34532898 19981204
- 国际公布: WO9952875 19991021
- 主分类号: C07D215/12
- IPC分类号: C07D215/12 ; A61K31/47 ; C07D215/14 ; C07D215/18 ; C07D215/20 ; C07D215/42 ; C07D215/58 ; C07D401/06 ; C07D401/10 ; C07D401/14 ; C07D403/06 ; C07D405/06 ; C07D409/10 ; C07D413/06 ; C07D413/14 ; C07D417/06 ; C07D417/14 ; C07D471/10
摘要:
The present invention provides a compound of formula (I) wherein Ar represents an aromatic group which may be substituted; X represents methylene, S, SO, SO2 or CO; Y represents a spacer having a main chain of 2 to 5 atoms; n represents an integer of 1 to 5; i) R?1 and R2¿ each represents a hydrogen atom or a lower alkyl which may be substituted, ii) R?1 and R2¿ form, taken together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring which may be substituted, or iii) R1 or R2 together with -(CH¿2?)n-N= form, bonded to a component atom of Ring B, a spiro-ring which may be substituted; Ring A represents an aromatic Ring which may be substituted; Ring B represents a 4- to 7-membered nitrogen-containing non-aromatic ring which may be further substituted by alkyl or acyl, with a proviso that X represents S, SO, SO2 or CO when Ring A has as a substituent a group represented by the formula: -NHCOR?11¿ where R11 represents alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or a group represented by the formula: -NHR12 where R12 represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, or a salt thereof; which has an excellent somatostatin receptor binding inhibition action.
信息查询