Patent search ipc:"C07D215/12" Page 1

1.

发明公开
METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE 审中-公开

公开(公告)号：EP4438042A3

公开(公告)日：2024-12-04

申请号：EP24181542.2

申请日：2019-06-22

Applicant: Ohio State Innovation Foundation , Hendrix College

Inventor： BYRD, John C. , GOODWIN, Thomas E. , ELGAMAL, Ola , HERTLEIN, Erin , ABDULRAHIM, Mouad , BENNETT, Chad E. , VIBHUTE, Sandip Madhukar

IPC: A61K31/573 , A61K31/519 , A61K31/506 , A61P17/06 , A61P35/00 , A61P37/06 , A61K45/06 , C07D215/12 , A61K31/47 , A61K31/436 , A61K31/451

Abstract: Disclosed herein are compounds, 3,4,6,8-substituted-2-([1,1'-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

2.

发明授权
NECROSIS INHIBITORS 有权

公开(公告)号：EP3224237B1

公开(公告)日：2024-09-11

申请号：EP15871953.4

申请日：2015-12-23

IPC: C07C233/05 , C07C235/06 , C07C275/06 , C07C311/03 , C07D213/06 , C07D215/12 , C07D233/64 , C07D277/20 , C07D333/06 , A61K31/16 , A61P31/00

CPC classification number: C07C255/60 , C07C259/06 , C07C275/24 , C07C311/14 , C07C313/06 , C07C233/05 , C07C233/13 , C07C233/18 , C07C233/47 , C07C233/59 , C07C235/10 , C07C237/06 , C07C237/22 , C07D217/14 , C07D231/12 , C07D333/20 , C07D277/28 , C07D211/28 , C07D213/40 , C07D213/61 , C07D213/64 , C07D307/14 , C07D307/52 , C07C2601/0220170501 , C07C2601/0420170501 , C07C2601/0820170501 , C07C2601/1020170501 , C07C2601/1420170501 , C07C2603/7420170501 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/06 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P37/00 , A61P37/06 , A61P39/02 , A61P43/00 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P3/10

3.

发明授权
N-BENZOYL-PHENYLALANINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS FOR TREATING INFLAMMATORY DISEASES 有权

公开(公告)号：EP3873897B1

公开(公告)日：2024-08-14

申请号：EP19805082.5

申请日：2019-10-29

IPC: C07D405/04 , C07C233/87 , C07D215/12 , C07D215/227 , C07D265/36 , C07D307/87 , C07D311/04 , C07D311/58 , C07D311/94 , C07D319/18 , C07D321/10 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04 , A61K31/4709 , A61P29/00

CPC classification number: C07D405/04 , C07D405/12 , C07D413/12 , C07D413/14 , C07D319/18 , C07D321/10 , C07D307/87 , C07D311/58 , C07D311/04 , C07D311/94 , C07D265/36 , C07D215/12 , C07D215/227 , C07D471/04 , C07D401/04 , C07D401/12 , C07C233/87 , A61P29/00 , C07C2602/0820170501

4.

发明公开
BENZOTHIAZOLYL BIARYL COMPOUND, AND PREPARATION METHOD AND USE 审中-公开

公开(公告)号：EP4144732A1

公开(公告)日：2023-03-08

申请号：EP20933967.0

申请日：2020-11-10

Applicant: Shanghai Ringene BioPharma Co., Ltd. , Shanghai Ringene Therapeutics Co. Ltd

Inventor： WAN, Huixin , ZHA, Chuantao , MA, Jingui , SHEN, Jingkang

IPC: C07D417/14 , C07D215/12 , C07D215/02 , C07D239/72 , C07D277/62 , A61K31/517 , A61P35/00

Abstract: A benzothiazolyl biaryl compound represented by general formula I, or a pharmaceutically acceptable salt thereof, or an enantiomer, a diastereoisomer, a tautomer, a torsional isomer, a solvate, a polymorph, or a prodrug thereof, a preparation method therefor, and a use thereof as a KRAS G12C inhibitor.