Compounds having a urea structure as the basic structure and carrying sulfur and amide bonds in side chains. It has been found out that these compounds have pharmacological effects, in particular, a TNF-α production inhibitory effect. The above compounds are represented by general formula [I] wherein R1 represents H, alkyl, an aromatic group, R?A-CO-, RC¿-S- or a group of formula [II]; R?2, R3 and R4¿ represent each H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or an aromatic group; R?5 and R6¿ represent each H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or an aromatic group, or R?5 and R6¿ may form together a nonaromatic heterocycle; R7 represents H, alkyl, cycloalkyl, hydroxy, mercapto, phenyl, R?B-O-, RC-S-, RD¿-COS-, RE-OCO-, RF-N(RG)- or -CONHOH; and A?1 and A2¿ represent each an alkylene.