发明授权
- 专利标题： ADENO-ASSOCIATED VIRUS VECTORS AND USES THEREOF
- 专利标题（中）： 腺相关病毒载体和用途
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申请号： EP99924404.9申请日： 1999-05-20
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公开(公告)号： EP1082444B1公开(公告)日： 2007-08-08
- 发明人: ENGELHARDT, John, F. , DUAN, Dongsheng
- 申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION
- 申请人地址： Oakdale Research Campus, 100 Oakdale Campus No. 214 Iowa City, IA 52242-5000 US
- 专利权人： UNIVERSITY OF IOWA RESEARCH FOUNDATION
- 当前专利权人： UNIVERSITY OF IOWA RESEARCH FOUNDATION
- 当前专利权人地址： Oakdale Research Campus, 100 Oakdale Campus No. 214 Iowa City, IA 52242-5000 US
- 代理机构： Beresford, Keith Denis Lewis
- 优先权： US86166P 19980520; US276625 19990325
- 国际公布： WO1999060146 19991125
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N15/10 ; C12N5/10 ; C07K14/47 ; A01K67/027 ; A61K31/70 ; A61K48/00
摘要：
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
公开/授权文献
- EP1082444A1 ADENO-ASSOCIATED VIRUS VECTORS AND USES THEREOF 公开/授权日：2001-03-14
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