公开(公告)号：EP4495236A3

公开(公告)日：2025-02-26

申请号：EP24195348.8

申请日：2019-12-19

Applicant: PARIS SCIENCES ET LETTRES ,  Centre National de la Recherche Scientifique ,  Institut Curie ,  The President and Fellows of Harvard College ,  HiFiBiO (HK) Limited ,  Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris ,  Institut National de la Santé et de la Recherche Médicale

Inventor： GRIFFITHS, Andrew ,  AMIGORENA, Sebastien ,  LANTZ, Olivier ,  WEITZ, David ,  NGHE, Philippe ,  GERARD, Annabelle

IPC: C12Q1/6806 ,  C12N15/10

Abstract: The invention concerns a method for identifying cognate pairs of a ligand species and a receptor species, comprising co-compartmentalising ligand species and receptor species to form a set of microreactors, each microreactor comprising at least one ligand species and preferably at least one receptor species; assaying the recognition between ligands and receptors in each microreactor and based on this assay, classifying each microreactor as positive when at least one ligand species and at least one receptor species in the microreactor recognize one with the other or negative when no ligand species and no receptor species recognize in the microreactor; identifying ligand species and receptor species contained in each positive microreactor; establishing a subset of positive microreactors containing the same receptor species; determining the probability that in a given subset of positive microreactors containing the same receptor species, the ligand species recognizing the receptor species corresponds to the most frequent co-compartmentalized ligand species; and if the determined probability is greater than a predetermined threshold, identifying as a cognate pair the receptor species and the most frequent co-compartmentalized ligand species.

公开(公告)号：EP3668978B1

公开(公告)日：2025-02-12

申请号：EP18845944.0

申请日：2018-08-20

Inventor： QIN, Jian ,  CHEN, Peilin ,  RAMAKRISHNAN, Ramesh

IPC: C12N15/10 ,  C12Q1/6806

公开(公告)号：EP4499823A2

公开(公告)日：2025-02-05

申请号：EP23775943.6

申请日：2023-03-27

Applicant: University of Maryland, Baltimore County

Inventor： BIEBERICH, Charles, J. ,  LI, Xiang

IPC: C12N15/10 ,  C12N15/11 ,  C12N15/66

公开(公告)号：EP4499821A1

公开(公告)日：2025-02-05

申请号：EP23717093.1

申请日：2023-03-31

Applicant: Ribbon Biolabs GmbH

Inventor： VLADAR, Harold Paul

IPC: C12N15/10 ,  G16B35/00 ,  C40B50/08

公开(公告)号：EP4499820A1

公开(公告)日：2025-02-05

申请号：EP23716269.8

申请日：2023-03-30

Applicant: Hun-Ren Biological Research Centre Szeged ,  HCEMM Nonprofit Kft. ,  Ramot at Tel-Aviv University Ltd.

Inventor： KINTSES, Balint ,  APJOK, Gábor ,  SZAMEL, Mónika ,  SARI, Tóbiás ,  MEHI, Orsolya Katinka ,  QIMRON, Ehud

IPC: C12N15/10 ,  C12N7/00 ,  C12N15/70 ,  C12N15/74 ,  C12Q1/68 ,  C40B40/02 ,  C40B40/06 ,  C40B50/06 ,  C12N15/86 ,  C12Q1/689 ,  C12Q1/70 ,  C07K14/01

公开(公告)号：EP4496888A1

公开(公告)日：2025-01-29

申请号：EP23778283.4

申请日：2023-03-29

Applicant: Shenzhen Bay Laboratory

Inventor： LIN, Xinli Henry ,  WU, Yundong ,  LU, Zhengchang

IPC: C12N9/68 ,  C12N15/57 ,  C07K14/47 ,  C12N15/10 ,  C12N15/70 ,  A61K38/48 ,  A61P7/02 ,  C12R1/19

公开(公告)号：EP4493688A2

公开(公告)日：2025-01-22

申请号：EP23720212.2

申请日：2023-03-17

Applicant: Yale University

Inventor： ISAACS, Farren ,  CRAWFORD, Jason ,  PATEL, Jaymin ,  OH, Joonseok ,  WANG, Shenqi

IPC: C12N15/10

公开(公告)号：EP4491719A1

公开(公告)日：2025-01-15

申请号：EP23382716.1

申请日：2023-07-12

Applicant: 4basebio, S.L.U. ,  Consejo Superior De Investigaciones Científicas

Inventor： MARTINEZ, Ana ,  PICHER, Ángel ,  BLANCO, Luis

IPC: C12N9/12 ,  C12N15/10 ,  C12Q1/6844

Abstract: The present invention is directed to methods of amplifying a nucleic acid molecule using a thermostable primase/polymerase protein, TthPrimPol, of a thermophile bacterial strain of Thermus thermophilus SG0.5JP17-16 , and the production of particular DNA molecules from DNA amplified by such methods. Amongst others, the present invention discloses primer-free methods, comprising TthPrimPol2, for amplification of low concentrations of DNA or RNA.

公开(公告)号：EP4490288A2

公开(公告)日：2025-01-15

申请号：EP23767727.3

申请日：2023-03-10

Applicant: Intima Bioscience, Inc.

Inventor： BUERCKSTUEMMER, Tilmann ,  SCHMIDT, Henrik ,  SIEBER, Anna ,  ILSINGER, Christoph

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/10 ,  C12N15/113 ,  C12N15/63

公开(公告)号：EP4486878A1

公开(公告)日：2025-01-08

申请号：EP23707740.9

申请日：2023-03-01

Applicant: BASF AGRICULTURAL SOLUTIONS SEED US LLC

Inventor： VAN DER OOST, John ,  VILLEGAS WARREN, Ricardo ,  LUTEIJN, Maartje Janneke ,  STAALS, Raymond Hubert Josèphe ,  WU, Wen Ying ,  DE VLEESSCHAUWER, David ,  D'HALLUIN, Katelijn ,  MEULEWAETER, Frank

IPC: C12N9/22 ,  C12N15/10 ,  A61K38/46 ,  A61K48/00 ,  C12N15/82 ,  C12N15/85 ,  C12N15/75