发明授权
- 专利标题： SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY
- 专利标题（中）： 多环芳基和杂取代的叔杂烷基，FOR胆固醇酯转移蛋白抑制活性
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申请号： EP99969710.5申请日： 1999-09-23
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公开(公告)号： EP1115693B1公开(公告)日： 2007-05-02
- 发明人: SIKORSKI, James, A. , DURLEY, Richard, C. , MISCHKE, Deborah, A. , REINHARD, Emily, J. , FOBIAN, Yvette, M. , TOLLEFSON, Michael, B. , WANG, Lijuan , GRAPPERHAUS, Margaret, L. , HICKORY, Brian, S. , MASSA, Mark, A. , NORTON, Monica, B. , VERNIER, William, F. , PARNAS, Barry, L. , PROMO, Michele, A. , HAMME, Ashton, T. , SPANGLER, Dale, P. , RUEPPEL, Melvin, L.
- 申请人： Monsanto Company
- 申请人地址： Corporate Patent Dept., P.O. Box 5110 Chicago, IL 60680-5110 US
- 专利权人： Monsanto Company
- 当前专利权人： Monsanto Company
- 当前专利权人地址： Corporate Patent Dept., P.O. Box 5110 Chicago, IL 60680-5110 US
- 代理机构： Albrecht, Thomas
- 优先权： US101663P 19980925
- 国际公布： WO2000018721 20000406
- 主分类号： C07C215/16
- IPC分类号： C07C215/16 ; C07C215/76 ; C07C215/50 ; C07C217/90 ; C07C217/84 ; C07D263/06 ; C07D251/16 ; A61K31/135 ; A61K31/33
摘要：
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
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