公开(公告)号：EP3638647B1

公开(公告)日：2024-01-17

申请号：EP18728666.1

申请日：2018-06-11

Inventor： SHINGE, Prashant Sukumar ,  SAINANI, Jaiprakash Brijlal

IPC: C07C213/02 ,  C07C249/02 ,  C07C215/76 ,  C07C251/24

公开(公告)号：EP4251605A1

公开(公告)日：2023-10-04

申请号：EP21897334.5

申请日：2021-11-11

Applicant: Laxmi Organic Industries Limited

Inventor： GOENKA, Ravi ,  AUDI, Ajay, A.

IPC: C07C215/76

公开(公告)号：EP3705477A1

公开(公告)日：2020-09-09

申请号：EP20155771.7

申请日：2005-06-24

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： HADIDA RUAH, Sarah S. ,  HAZLEWOOD, Anna R. ,  GROOTENHUIS, Peter D. J. ,  VAN GOOR, Frederick F. ,  SINGH, Ashvani K. ,  ZHOU, Jinglan ,  McCARTNEY, Jason

IPC: C07D401/12 ,  C07D215/56 ,  C07D417/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：EP2755944B1

公开(公告)日：2017-06-14

申请号：EP12762245.4

申请日：2012-09-07

Applicant: SANOFI

Inventor： FEUTRILL, John ,  LERICHE, Caroline ,  MIDDLEMISS, David

IPC: C07C215/76 ,  C07C217/84 ,  C07C65/105 ,  C07C65/24 ,  C07C255/57 ,  C07C255/58 ,  C07C255/59 ,  C07C233/75 ,  C07D295/088 ,  A61K31/165 ,  A61P27/06

CPC classification number: C07C217/84 ,  A61K9/0014 ,  A61K9/0048 ,  A61K31/165 ,  A61K31/196 ,  A61K31/216 ,  A61K31/277 ,  A61K31/5375 ,  A61K45/06 ,  C07C63/72 ,  C07C65/105 ,  C07C65/24 ,  C07C213/02 ,  C07C213/08 ,  C07C215/76 ,  C07C233/75 ,  C07C235/20 ,  C07C235/56 ,  C07C237/30 ,  C07C253/30 ,  C07C255/57 ,  C07C255/58 ,  C07C255/59 ,  C07D295/088

公开(公告)号：EP1727782B1

公开(公告)日：2012-08-22

申请号：EP05727512.5

申请日：2005-03-25

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： KIYOKAWA, Hiroshi ,  AKI, Shinji

IPC: C07C213/02 ,  C07D295/08 ,  C07D211/46 ,  C07C215/82 ,  C07C215/76

CPC classification number: C07D295/096 ,  C07C213/02 ,  C07C215/76 ,  C07C215/82

Abstract: The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a method of producing an aminophenol compound represented by the formula (1): (wherein each of R1 and R2, which may be the same or different, is a hydrogen atom, a substituted or unsubstituted lower alkyl group or the like; R1 and R2, taken together with the adjacent nitrogen atom, may form a 5- or 6-membered heterocycle with or without other intervening heteroatoms; the heterocycle may be substituted by 1 to 3 substituents selected from the group consisting of a hydroxyl group, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aryloxy group and the like; and the hydroxyl group in the formula (1) is substituted on the 2- or 4-position to the amino group on the phenyl ring), which comprises allowing a cyclohexanedione compound represented by the formula (2) to react with an amine compound represented by the formula (3) (wherein R1 and R2 are as defined above), under a neutral or basic condition.

公开(公告)号：EP2244998A2

公开(公告)日：2010-11-03

申请号：EP09712829.2

申请日：2009-02-19

Applicant: Helmholtz-Zentrum für Infektionsforschung GmbH

Inventor： GERTH, Klaus ,  STEINMETZ, Heinrich ,  HÖFLE, Gerhard

IPC: C07C59/72 ,  A61K31/202 ,  A61K31/335 ,  C07C59/54 ,  C07C229/56 ,  C07D313/00 ,  C12P7/42 ,  C12P13/00 ,  C12P17/08 ,  C07C225/22 ,  C07C215/76 ,  C07D307/54 ,  C07D333/24

CPC classification number: C07C59/72 ,  C07C59/54 ,  C07C229/56 ,  C07C2602/08 ,  C07D313/00 ,  C12P7/42 ,  C12P13/001 ,  C12P17/08

Abstract: The present invention describes Elansolids, a new class of novel anti-bacterial compounds of formula (I).

Abstract translation: 本发明描述了伊兰固体，一类新的式（I）的新型抗细菌化合物的：

公开(公告)号：EP1115693B9

公开(公告)日：2007-12-19

申请号：EP99969710.5

申请日：1999-09-23

Applicant: Monsanto Company

Inventor： SIKORSKI, James, A. ,  DURLEY, Richard, C. ,  MISCHKE, Deborah, A. ,  REINHARD, Emily, J. ,  FOBIAN, Yvette, M. ,  TOLLEFSON, Michael, B. ,  WANG, Lijuan ,  GRAPPERHAUS, Margaret, L. ,  HICKORY, Brian, S. ,  MASSA, Mark, A. ,  NORTON, Monica, B. ,  VERNIER, William, F. ,  PARNAS, Barry, L. ,  PROMO, Michele, A. ,  HAMME, Ashton, T. ,  SPANGLER, Dale, P. ,  RUEPPEL, Melvin, L.

IPC: C07C215/16 ,  C07C215/76 ,  C07C215/50 ,  C07C217/90 ,  C07C217/84 ,  C07D263/06 ,  C07D251/16 ,  A61K31/135 ,  A61K31/33

CPC classification number: C07D207/335 ,  A61K31/135 ,  A61K31/33 ,  C07C215/16 ,  C07C215/50 ,  C07C215/76 ,  C07C217/58 ,  C07C217/84 ,  C07C217/86 ,  C07C217/88 ,  C07C217/90 ,  C07C219/34 ,  C07C225/22 ,  C07C229/60 ,  C07C233/69 ,  C07C235/38 ,  C07C237/30 ,  C07C237/38 ,  C07C255/55 ,  C07C255/58 ,  C07C275/34 ,  C07C291/04 ,  C07C311/04 ,  C07C311/21 ,  C07C311/24 ,  C07C311/60 ,  C07C317/32 ,  C07C317/36 ,  C07C323/19 ,  C07C323/25 ,  C07C323/31 ,  C07C323/32 ,  C07C323/37 ,  C07C323/44 ,  C07C323/65 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/18 ,  C07D209/08 ,  C07D213/26 ,  C07D213/30 ,  C07D213/643 ,  C07D213/66 ,  C07D213/85 ,  C07D239/34 ,  C07D251/16 ,  C07D251/42 ,  C07D263/06 ,  C07D295/135 ,  C07D295/192 ,  C07D307/14 ,  C07D307/42 ,  C07D307/52 ,  C07D309/12 ,  C07D333/20 ,  C07D333/28

Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.

Abstract translation: 本发明涉及可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-I）抑制剂的取代的多环芳基和杂芳基叔杂烷基胺化合物以及用于治疗动脉粥样硬化和其他冠状动脉疾病的化合物，组合物和方法。

公开(公告)号：EP1052238A4

公开(公告)日：2007-05-02

申请号：EP99900676

申请日：1999-01-26

Applicant: SHIONOGI & CO

Inventor： TANIMOTO NORIHIKO ,  HASEGAWA YASUSHI ,  HAGA NOBUHIRO

IPC: C07C43/215 ,  A61K31/07 ,  A61K31/075 ,  A61P37/00 ,  C07C43/20 ,  C07C43/23 ,  C07C43/285 ,  C07C49/84 ,  C07C205/38 ,  C07C215/76 ,  C07C215/82 ,  C07C217/54 ,  C07C217/58 ,  C07C217/80 ,  C07C217/84 ,  C07C217/86 ,  C07C217/90 ,  C07C233/25 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D213/76 ,  C07D231/12 ,  C07D237/12 ,  C07D237/14 ,  C07D239/26 ,  C07D239/36 ,  C07D241/12 ,  C07D261/08 ,  C07D263/32 ,  C07D277/06 ,  C07D307/38 ,  C07D333/06 ,  C07D401/10 ,  A61K31/44 ,  C07C43/295

CPC classification number: C07D401/10 ,  C07C43/20 ,  C07C43/23 ,  C07C215/76 ,  C07C215/82 ,  C07C217/54 ,  C07C217/58 ,  C07C217/84 ,  C07C217/86 ,  C07C217/90 ,  C07C233/25 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D213/76 ,  C07D231/12 ,  C07D237/12 ,  C07D237/14 ,  C07D239/26 ,  C07D239/36 ,  C07D241/12 ,  C07D261/08 ,  C07D263/32 ,  C07D277/06 ,  C07D307/38 ,  C07D333/06

Abstract: A compound represented by formula (1) wherein each of ring A, ring B and ring C is independently a substituted or unsubstituted aromatic ring or a substituted or unsubstituted five or six-membered heterocycle which may be condensed with a benzene ring, when ring A, ring B and/or ring C is a substituted or unsubstituted five-membered heterocycle W1, W2 and/or W3 represents a bonding, X is D- or -NR1- (where R¿1? is hydrogen, a lower alkyl or the like), Y is hydrogen, a lower alkyl, a lower alkenyl or the like, and, for V?1 and V2¿ one is a single bond and the other is a single bond, -O- or the like, and a medicine comprising the compound.

公开(公告)号：EP1773816A2

公开(公告)日：2007-04-18

申请号：EP05791060.6

申请日：2005-06-24

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： HADIDA RUAH, Sarah, S. ,  HAZLEWOOD, Anna, R. ,  GROOTENHUIS, Peter, D., J. ,  VAN GOOR, Frederick, F. ,  SINGH, Ashvani, K. ,  ZHOU, Jinglan ,  MCCARTNEY, Jason

IPC: C07D401/12 ,  C07D209/12 ,  C07D215/56 ,  C07D209/14 ,  C07D417/12 ,  C07D209/18 ,  C07D405/12 ,  A61K31/47 ,  C07D409/12 ,  A61K31/4709 ,  C07D413/12 ,  A61P25/00 ,  C07C215/76 ,  A61P31/00 ,  C07D209/08

CPC classification number: C07D471/10 ,  A61K8/4926 ,  A61K31/04 ,  A61K31/136 ,  A61K31/265 ,  A61K31/27 ,  A61K31/277 ,  A61K31/352 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4747 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  C07C205/11 ,  C07C205/58 ,  C07C209/00 ,  C07C211/17 ,  C07C211/50 ,  C07C211/52 ,  C07C215/28 ,  C07C215/70 ,  C07C215/76 ,  C07C215/78 ,  C07C217/76 ,  C07C217/80 ,  C07C217/84 ,  C07C219/34 ,  C07C229/52 ,  C07C255/58 ,  C07C271/20 ,  C07C311/08 ,  C07C311/39 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2603/74 ,  C07D209/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/20 ,  C07D209/42 ,  C07D209/94 ,  C07D209/96 ,  C07D213/20 ,  C07D213/73 ,  C07D215/227 ,  C07D215/233 ,  C07D215/38 ,  C07D215/56 ,  C07D217/04 ,  C07D217/06 ,  C07D223/16 ,  C07D265/36 ,  C07D279/16 ,  C07D311/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  G01N33/48728 ,  G01N33/5035 ,  G01N33/566 ,  G01N33/6872 ,  G01N2333/705

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：EP1589000A3

公开(公告)日：2006-03-15

申请号：EP05011025.3

申请日：1999-09-23

Applicant: Monsanto Company

Inventor： Sikorski, James.A ,  Durley, Richard.C ,  Mischke, Deborah.a ,  Reinhard, Emily.J ,  Fobian, Yvette.M ,  Tollefson, Michael.B ,  Wang, Lijuan. ,  Grapperhaus, Margaret.L ,  Hickory, Brian.S ,  Massa, Mark.A ,  Norton, Monica.B ,  Vernier, William.F ,  Promo, Michele.A ,  Hamme, Ashton.T ,  Spangler, Dale.P ,  Rueppel, Melvin.L

IPC: C07C215/16 ,  C07C215/76 ,  C07C215/50 ,  C07C217/90 ,  C07C217/84 ,  C07D263/06 ,  C07D251/16 ,  A61K31/135 ,  A61K31/33

CPC classification number: C07D207/335 ,  A61K31/135 ,  A61K31/33 ,  C07C215/16 ,  C07C215/50 ,  C07C215/76 ,  C07C217/58 ,  C07C217/84 ,  C07C217/86 ,  C07C217/88 ,  C07C217/90 ,  C07C219/34 ,  C07C225/22 ,  C07C229/60 ,  C07C233/69 ,  C07C235/38 ,  C07C237/30 ,  C07C237/38 ,  C07C255/55 ,  C07C255/58 ,  C07C275/34 ,  C07C291/04 ,  C07C311/04 ,  C07C311/21 ,  C07C311/24 ,  C07C311/60 ,  C07C317/32 ,  C07C317/36 ,  C07C323/19 ,  C07C323/25 ,  C07C323/31 ,  C07C323/32 ,  C07C323/37 ,  C07C323/44 ,  C07C323/65 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/18 ,  C07D209/08 ,  C07D213/26 ,  C07D213/30 ,  C07D213/643 ,  C07D213/66 ,  C07D213/85 ,  C07D239/34 ,  C07D251/16 ,  C07D251/42 ,  C07D263/06 ,  C07D295/135 ,  C07D295/192 ,  C07D307/14 ,  C07D307/42 ,  C07D307/52 ,  C07D309/12 ,  C07D333/20 ,  C07D333/28

Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.

Abstract translation: 本发明涉及substituiertem芳基和杂芳基（R） - 手性卤化1- Substitutedamino-第（n + 1）链烷醇化合物可用作胆固醇酯转移蛋白抑制剂（CETP;血浆脂质转移蛋白-I）和化合物，组合物和方法 用于治疗动脉粥样硬化和其它冠状动脉疾病。 新颖高收率，对于从手性和非手性中间体手性substituiertem链烷醇化合物的制备立体有择方法描述。