发明公开
EP1123401A1 BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
审中-公开
生物活性肽和甲状旁腺激素（PTH）和甲状旁腺激素相关肽肽衍生物（PTHrP的）
- 专利标题： BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
- 专利标题（中）： 生物活性肽和甲状旁腺激素（PTH）和甲状旁腺激素相关肽肽衍生物（PTHrP的）
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申请号： EP99970686.4申请日： 1999-10-20
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公开(公告)号： EP1123401A1公开(公告)日： 2001-08-16
- 发明人: GARDELLA, Thomas, J. , KRONENBERG, Henry, M. , POTTS, John, T., Jr. , JÜPPNER, Harald
- 申请人： THE GENERAL HOSPITAL CORPORATION
- 申请人地址： Fruit Street Boston, MA 02114 US
- 专利权人： THE GENERAL HOSPITAL CORPORATION
- 当前专利权人： THE GENERAL HOSPITAL CORPORATION
- 当前专利权人地址： Fruit Street Boston, MA 02114 US
- 代理机构： Chapman, Paul William
- 优先权： US105530P 19981022
- 国际公布： WO0023594 20000427
- 主分类号： C12N15/16
- IPC分类号： C12N15/16 ; C07K14/635 ; A61K38/29 ; C12P21/02 ; C12N1/19 ; C12N1/21 ; C12N5/16 ; C12N5/14
摘要：
Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
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