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公开(公告)号：EP0579758A1
公开(公告)日：1994-01-26
申请号：EP92910874.0
申请日：1992-04-06
发明人： SEGRE, Gino, V. , KRONENBERG, Henry, M. , ABOU-SAMRA, Abdul-Badi , JUPPNER, Harald , POTTS, John, T., Jr. , SCHIPANI, Ernestina
IPC分类号： A01K67 , A61K38 , A61K39 , A61P3 , A61P5 , C07K5 , C07K7 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , G01N33 , C12R1
CPC分类号： C12N15/1138 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , C07K14/635 , C07K14/705 , C07K14/72 , C07K14/721 , C07K16/2869 , C12N15/8509 , G01N33/78 , G01N33/84 , G01N2800/04 , G01N2800/046
摘要： ADN codant un récepteur d'hormone parathyroïdienne; production et isolation de polypeptides et de fragments synthétiques et de recombinaison de récepteurs d'hormone parathyroïdienne; anticorps contre les récepteurs d'hormone parathyroïdienne et les fragments de récepteurs; procédé de criblage de composés susceptibles de présenter des effets antagonistes ou agonistes sur l'action des récepteurs d'hormone parathyroïdienne; et procédés diagnostiques et thérapeutiques utilisant ces composés.
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公开(公告)号：EP1133560B1
公开(公告)日：2010-02-17
申请号：EP99959086.2
申请日：1999-11-24
CPC分类号： C07K14/635 , A61K38/00
摘要： Synthetic and/or recombinant biologically active peptide derivatives of PTH(1-28), comprising a biologically active peptide at least 90 % identical to a peptide consisting essentially of the formula: (a) X01ValSerGluIleGlnLeuMetHisAsnLeuGlyLysHisLeuAsnSerMetX02ArgValGluTrpLeuArgLysLysLeu(SEQ ID NO:1); (b) fragments thereof containing amino acids 1-24, 1-25, 1-26, or 1-27; (c) pharmaceutically acceptable salts thereof; or (d) N- or C- derivatives thereof; wherein: X01 is Ser, Ala or Gly; and X02 is Glu or Arg, provided that said peptide is not hPTH(1-26)NH2, hPTH(1-27)NH2 or hPTH(1-28)NH2.
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3.发明公开PURPOSEFUL MOVEMENT OF HUMAN MIGRATORY CELLS AWAY FROM AN AGENT SOURCE 审中-公开GEZIELTE WEGBEWEGUNG MENSCHLICHER MIGRATIONSZELLEN VON EINER WIRKSTOFFQUELLE
公开(公告)号：EP1814587A2
公开(公告)日：2007-08-08
申请号：EP05858305.5
申请日：2005-11-04
IPC分类号： A61K39/395
CPC分类号： A61K39/0011 , A61K31/00 , A61K31/33 , A61K31/337 , A61K31/395 , A61K33/24 , A61K38/19 , C07K16/2866 , G01N2333/726 , G01N2500/02
摘要： This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides fugetactic agents and methods for the use thereof in enhancing an immune response.
摘要翻译： 本发明提供用于调节具有迁移能力的真核细胞运动的方法和组合物。 更具体地，本发明提供抗融合剂及其用于增强免疫应答的方法。
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公开(公告)号：EP0579758B1
公开(公告)日：2005-01-26
申请号：EP92910874.4
申请日：1992-04-06
发明人： SEGRE, Gino, V. , KRONENBERG, Henry, M. , ABOU-SAMRA, Abdul-Badi , JUPPNER, Harald , POTTS, John, T., Jr. , SCHIPANI, Ernestina
CPC分类号： C12N15/1138 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , C07K14/635 , C07K14/705 , C07K14/72 , C07K14/721 , C07K16/2869 , C12N15/8509 , G01N33/78 , G01N33/84 , G01N2800/04 , G01N2800/046
摘要： DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
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公开(公告)号：EP1141237B1
公开(公告)日：2005-11-02
申请号：EP98965037.9
申请日：1998-12-31
CPC分类号： C07K14/72 , C07K2319/00 , G01N33/5008 , G01N33/5038 , G01N33/5044 , G01N2333/72
摘要： The invention provides a novel PTH receptor polypeptide, r delta Nt, characterized by a deletion of the extracellular amino-terminus, ligand binding domain of the receptor. Additionally disclosed are nucleic acid molecules encoding the receptor. The receptor has a minimal domain for ligand binding and is useful in screening assays designed for the identification of agonists and antagonists of PTH receptor activity.
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公开(公告)号：EP1133560A1
公开(公告)日：2001-09-19
申请号：EP99959086.2
申请日：1999-11-24
CPC分类号： C07K14/635 , A61K38/00
摘要： Synthetic and/or recombinant biologically active peptide derivatives of PTH(1-28), comprising a biologically active peptide at least 90 % identical to a peptide consisting essentially of the formula: (a) X01ValSerGluIleGlnLeuMetHisAsnLeuGlyLysHisLeuAsnSerMetX02ArgValGluTrpLeuArgLysLysLeu(SEQ ID NO:1); (b) fragments thereof containing amino acids 1-24, 1-25, 1-26, or 1-27; (c) pharmaceutically acceptable salts thereof; or (d) N- or C- derivatives thereof; wherein: X01 is Ser, Ala or Gly; and X02 is Glu or Arg, provided that said peptide is not hPTH(1-26)NH2, hPTH(1-27)NH2 or hPTH(1-28)NH2.
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7.发明公开
公开(公告)号：EP1610813A1
公开(公告)日：2006-01-04
申请号：EP03716681.6
申请日：2003-03-19
发明人： GARDELLA, Thomas, J. , POTTS, John, T., Jr. , KRONENBERG, Henry, M. , SHIMIZU, Naoto, Chugai Pharmaceutical Co., Ltd , CARTER, Percy
IPC分类号： A61K38/29 , C07K1/06 , C07K14/635
CPC分类号： C07K14/635 , A61K38/29
摘要： The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs and derivatives of those analogs. The invention also provides methods of preparing and using the PTH analogs. Further, the invention encompasses compositions and methods for use in limiting undesired bone loss in a vertebrate at risk of such bone loss, in treating conditions that are characterized by undesired bone loss or by the need for bone growth, e.g. in treating fractures or cartilage disorders and for raising camp levels in cells where deemed necessary.
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公开(公告)号：EP1141237A1
公开(公告)日：2001-10-10
申请号：EP98965037.9
申请日：1998-12-31
CPC分类号： C07K14/72 , C07K2319/00 , G01N33/5008 , G01N33/5038 , G01N33/5044 , G01N2333/72
摘要： The invention provides a novel PTH receptor polypeptide, rδNt, characterized by a deletion of the extracellular amino-terminus, ligand binding domain of the receptor. Additionally disclosed are nucleic acid molecules encoding the receptor. The receptor has a minimal domain for ligand binding and is useful in screening assays designed for the identification of agonists and antagonists of PTH receptor activity.
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9.发明公开BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP) 审中-公开生物活性肽和甲状旁腺激素（PTH）和甲状旁腺激素相关肽肽衍生物（PTHrP的）
公开(公告)号：EP1123401A1
公开(公告)日：2001-08-16
申请号：EP99970686.4
申请日：1999-10-20
CPC分类号： C07K7/08 , A61K38/00 , C07K14/635
摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
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