发明公开
EP1125925A1 Amine derivatives for the treatment of apoptosis
审中-公开
Amin-Derivate zur Behandlung von Apoptosis
- 专利标题： Amine derivatives for the treatment of apoptosis
- 专利标题（中）： Amin-Derivate zur Behandlung von Apoptosis
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申请号： EP00810128.9申请日： 2000-02-15
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公开(公告)号： EP1125925A1公开(公告)日： 2001-08-22
- 发明人: Halazy, Serge , Schwarz, Matthias , Antonsson, Bruno , Bombrun, Agnès , Martinou, Jean-Claude , Church, Dennis
- 申请人： Applied Research Systems ARS Holding N.V.
- 申请人地址： Pietermaai 15, P.O. Box 4905 Curacao AN
- 专利权人： Applied Research Systems ARS Holding N.V.
- 当前专利权人： Applied Research Systems ARS Holding N.V.
- 当前专利权人地址： Pietermaai 15, P.O. Box 4905 Curacao AN
- 代理机构： Hassa, Jürgen
- 主分类号： C07D211/60
- IPC分类号： C07D211/60 ; A61K31/445 ; C07D207/16 ; A61K31/40 ; A61P43/00 ; C07D277/06 ; A61K31/425 ; A61K31/47 ; C07D217/26 ; C07C233/00 ; C07C235/00
摘要：
The present invention is related to substituted amine derivatives I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such piperazine derivatives of carbazole. Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.
A 1 and A 2 are selected independently from each other from the group consisting of -C(O)- and -SO 2 -.
R a , R b , R 0 , R 1 and R 2 are as the application.
A 1 and A 2 are selected independently from each other from the group consisting of -C(O)- and -SO 2 -.
R a , R b , R 0 , R 1 and R 2 are as the application.
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