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1.发明公开
公开(公告)号：EP1799248A1
公开(公告)日：2007-06-27
申请号：EP05786995.0
申请日：2005-09-21
发明人： SAGOT, Yves , POULY, Sandrine
CPC分类号： A61K38/1709 , A61K38/00 , A61K38/19 , A61K38/215 , A61K48/00 , C07K14/54 , A61K2300/00
摘要： The invention relates to the use of IL-17F, or of an agonist of IL-17F activity, for treatment or prevention of neurologic diseases.
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2.发明授权Process for stepwise attachment of polyethylene glycol (PEG) to a polypeptide 有权一种用于聚乙二醇（PEG）的分步附着到多肽的方法
公开(公告)号：EP1421956B1
公开(公告)日：2007-06-27
申请号：EP04003053.8
申请日：1999-04-28
IPC分类号： A61K47/48
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
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3.发明公开PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS 有权PYRIDINMETHYLENZOLIDINONE及其作为抑制剂磷酸肌醇
公开(公告)号：EP1786812A1
公开(公告)日：2007-05-23
申请号：EP05797231.7
申请日：2005-09-02
发明人： RUECKLE, Thomas , QUATTROPANI, Anna , POMEL, Vincent , DORBAIS, Jérôme , COVINI, David , BISCHOFF, Alexander
IPC分类号： C07D471/04 , C07D491/04 , A61K31/4355 , A61K31/519 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention is related to fused pyridine methylene azolidinone derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
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公开(公告)号：EP1786457A1
公开(公告)日：2007-05-23
申请号：EP05777754.2
申请日：2005-08-30
CPC分类号： A61K38/204
摘要： Abstract The present invention relates to the use of IL-6 or a fragment, variant, fusion protein, functional derivative or salt thereof in microvascular complications.
摘要翻译： 本发明涉及IL-6或其片段，变体，融合蛋白，功能性衍生物或其盐在微血管并发症中的用途。
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公开(公告)号：EP1411970B1
公开(公告)日：2007-04-18
申请号：EP01995681.2
申请日：2001-11-30
CPC分类号： A61K38/215 , A61K38/00 , A61K48/00 , C07K14/52 , A61K2300/00
摘要： The invention relates to the use of SARP-1 (secreted apoptosis-related protein 1) for the preparation of a medicament for the treatment and/or prevention of scleroderma, in particular of systemic sclerosis.
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公开(公告)号：EP1515990B1
公开(公告)日：2007-04-11
申请号：EP03759978.4
申请日：2003-06-03
CPC分类号： C07K14/522 , A61K38/00
摘要： Novel antagonists of CXCR3 -binding CXC chemokines, and in particular of human CXCL11, can be obtained by generating mutants of such chemokines in which the binding to glycosaminoglycans (GAGs) is impaired due to non-conservative substitutions of amino acids involved in this interaction. Compounds prepared in accordance with the present invention can be used to block the activity of CXCR3-binding CXC chemokines on CXCR3 -expressing cells, thereby providing therapeutic compositions for use in the treatment or prevention of diseases related to excessive activated T cells migration, such as graft rejection and autoimmune diseases, and of diseases needing an increase of vascularization, such as ischemic heart disease.
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公开(公告)号：EP1750513A2
公开(公告)日：2007-02-14
申请号：EP05804783.8
申请日：2005-04-19
CPC分类号： A61K38/1709 , A61K38/24 , A61K2300/00
摘要： The present invention is directed to methods and compositions for the treatment of infertility.
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8.发明公开USE OF IL-6 IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR TREATING AND PREVENTING LIVER INJURY 有权IL-6的药物组合物的生产中使用，用于治疗和预防肝损伤
公开(公告)号：EP1744777A2
公开(公告)日：2007-01-24
申请号：EP04806689.8
申请日：2004-12-23
CPC分类号： A61K38/204
摘要： The invention relates to the use of IL-6 in liver cirrhosis.
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9.发明授权METHOD FOR THE PREPARATION OF 21-HYDROXY-6,19-OXIDOPROGESTERONE (21OH-6OP) 有权用于生产21羟基6,19-oxidoprogesterone（21OH-6OP）
公开(公告)号：EP1325022B1
公开(公告)日：2006-11-02
申请号：EP01984642.7
申请日：2001-09-17
IPC分类号： C07J71/00
CPC分类号： C07J71/00 , C07J71/0005
摘要： The present invention relates to a novel method for preparing 21-hydroxy-6,19-oxidopro-gesterone (21OH-6OP) and/or its 21-acetate, 21-propionate, 21-hemisuccinate, 21-phosphate, 21-oleate derivatives. 21OH-6OP and its ester derivatives are antiglucocorticoids for the treatment or prophy laxis of diseases associated to an excess of glucocorticoids, in particular for treating Cushing's syndrome, iatrogenic hypercortisolism or depression.
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10.发明授权USE OF HUMAN GROWTH HORMONE TO INCREASE THE NUMBER OF CIRCULATING CD34+ CELLS, INTENDED FOR RECONSTITUTION OF THE HEMATOPOIETIC AND IMMUNE SYSTEMS FOLLOWING MYELOABLATIVE OR ANTIBLASTIC THERAPIES, BY TRANSPLANTATION, RE-INFUSION OR ENGRAFTMENT 有权人生长激素的用于再现循环的CD34 +细胞用于恢复免疫系统和HÄMAPOIETISCHEN-以下清髓OR ANTIBLASTISCHER治疗移植或再输注的数目的使用
公开(公告)号：EP1140149B1
公开(公告)日：2006-10-11
申请号：EP99965579.8
申请日：1999-12-30
CPC分类号： A61K38/27 , A61K35/00 , A61K2300/00
摘要： The invention relates to the field of hematopoietic CD34+ cell mobilization. In particular, this invention relates to a method for increasing the mobilization of pluripotent hematopoetic CD34+ cells by administration of human growth hormone or one of its derivates to the individual.
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