发明公开
EP1134222A1 IMIDAZO[4,5-b]PYRIDINIUMMETHYL-CONTAINING CEPHEM COMPOUNDS HAVING BROAD ANTIBACTERIAL SPECTRUM
有权
WITH A咪唑并[4,5-B]吡啶鎓甲基REST THAT广谱抗菌作用HAVE头孢烯
- 专利标题： IMIDAZO[4,5-b]PYRIDINIUMMETHYL-CONTAINING CEPHEM COMPOUNDS HAVING BROAD ANTIBACTERIAL SPECTRUM
- 专利标题（中）： WITH A咪唑并[4,5-B]吡啶鎓甲基REST THAT广谱抗菌作用HAVE头孢烯
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申请号： EP99973033.6申请日： 1999-11-25
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公开(公告)号： EP1134222A1公开(公告)日： 2001-09-19
- 发明人: NISHITANI, Yasuhiro-Shionogi & Co., Ltd. , ITANI, Hikaru-Shionogi & Co., Ltd. , IRIE, Tadashi-Shionogi & Co., Ltd.
- 申请人： SHIONOGI & CO., LTD.
- 申请人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人： SHIONOGI & CO., LTD.
- 当前专利权人： SHIONOGI & CO., LTD.
- 当前专利权人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP33670798 19981127
- 国际公布： WO0032606 20000608
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; C07D471/04 ; A61K31/546 ; A61P31/04
摘要：
A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA.
wherein, X is N or CY and Y is H or halogen; R 1 is amino or protected amino; R 2 is hydrogen or optionally substituted lower alkyl etc.; R 3 is hydrogen etc.; R 4 is hydrogen, optionally substituted lower alkyl, or optionally substituted N-containing heterocyclic group etc.; R 5 is hydrogen etc.; and a wavy line means syn- or anti-isomerism or a mixture thereof.
wherein, X is N or CY and Y is H or halogen; R 1 is amino or protected amino; R 2 is hydrogen or optionally substituted lower alkyl etc.; R 3 is hydrogen etc.; R 4 is hydrogen, optionally substituted lower alkyl, or optionally substituted N-containing heterocyclic group etc.; R 5 is hydrogen etc.; and a wavy line means syn- or anti-isomerism or a mixture thereof.
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