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1.发明公开IMIDAZO[4,5-b]PYRIDINIUMMETHYL-CONTAINING CEPHEM COMPOUNDS HAVING BROAD ANTIBACTERIAL SPECTRUM 有权WITH A咪唑并[4,5-B]吡啶鎓甲基REST THAT广谱抗菌作用HAVE头孢烯
公开(公告)号：EP1134222A1
公开(公告)日：2001-09-19
申请号：EP99973033.6
申请日：1999-11-25
申请人： SHIONOGI & CO., LTD.
发明人： NISHITANI, Yasuhiro-Shionogi & Co., Ltd. , ITANI, Hikaru-Shionogi & Co., Ltd. , IRIE, Tadashi-Shionogi & Co., Ltd.
IPC分类号： C07D519/00 , C07D471/04 , A61K31/546 , A61P31/04
CPC分类号： C07D501/00
摘要： A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA.
wherein, X is N or CY and Y is H or halogen; R 1 is amino or protected amino; R 2 is hydrogen or optionally substituted lower alkyl etc.; R 3 is hydrogen etc.; R 4 is hydrogen, optionally substituted lower alkyl, or optionally substituted N-containing heterocyclic group etc.; R 5 is hydrogen etc.; and a wavy line means syn- or anti-isomerism or a mixture thereof.-
2.发明授权IMIDAZO[4,5-b]PYRIDINIUMMETHYL-CONTAINING CEPHEM COMPOUNDS HAVING BROAD ANTIBACTERIAL SPECTRUM 有权WITH A咪唑并[4,5-B]吡啶鎓甲基REST THAT广谱抗菌作用HAVE头孢烯
公开(公告)号：EP1134222B1
公开(公告)日：2005-04-13
申请号：EP99973033.6
申请日：1999-11-25
申请人： SHIONOGI & CO., LTD.
发明人： NISHITANI, Yasuhiro-Shionogi & Co., Ltd. , ITANI, Hikaru-Shionogi & Co., Ltd. , IRIE, Tadashi-Shionogi & Co., Ltd.
IPC分类号： C07D519/00 , C07D471/04 , A61K31/546 , A61P31/04
CPC分类号： C07D501/00
摘要： Cephem compounds represented by general formula (I) which have a broad antibacterial spectrum over various pathogenic bacteria and are also efficacious against MRSA, wherein X represents N or CY (wherein Y represents H or halogeno); R1 represents optionally protected amino; R2 represents hydrogen, optionally substituted lower alkyl, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, optionally substituted lower alkyl, an optionally substituted nitrogen-containing heterocycle, etc.; R5 represents hydrogen, etc.; and the wavy lines means syn- or anti-isomerism or a mixture thereof.
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