发明授权
EP1135389B1 DERIVES DE 1,4-DIAZABICYCLO 3.2.2]NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
有权
1,4-二氮杂双环（3.2.2）壬烷，其制备方法及其在医学
- 专利标题： DERIVES DE 1,4-DIAZABICYCLO 3.2.2]NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
- 专利标题（英）： 1,4-diazabicyclo 3.2.2]nonane derivatives, their preparation and therapeutic application
- 专利标题（中）： 1,4-二氮杂双环（3.2.2）壬烷，其制备方法及其在医学
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申请号： EP99973291.0申请日： 1999-12-01
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公开(公告)号： EP1135389B1公开(公告)日： 2003-09-10
- 发明人: LOCHEAD, Alistair , JEGHAM, Samir , NEDELEC, Alain , GALLI, Frédéric , JEUNESSE, Jean , EVEN, Luc
- 申请人： SANOFI-SYNTHELABO
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： SANOFI-SYNTHELABO
- 当前专利权人： SANOFI-SYNTHELABO
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Ludwig, Jacques
- 优先权： FR9815326 19981204
- 国际公布： WO00034279 20000615
- 主分类号： C07D471/08
- IPC分类号： C07D471/08 ; A61K31/551
摘要：
The invention concerns compounds of general formula (I) wherein one of the symbols X, Y and Z represents a nitrogen atom, another represents a group of formula C-R3 and the third represents a nitrogen atom or a group of formula C-R4; R3 and R4 represent each, independently of each other, a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, (C1-C6)alkyl or (C1-C6) alkoxy group; R1 and R2 represent each, independently of each other, a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, or phenyl group optionally substituted. The invention is applicable in therapy.
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