发明公开
- 专利标题： DIMETHYLARGININE DIMETHYLAMINOHYDROLASES
- 专利标题（中）： 二甲基精氨酸DIMETHYLAMINOHYDROLASEN
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申请号： EP00901731.0申请日： 2000-01-26
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公开(公告)号： EP1144605A2公开(公告)日： 2001-10-17
- 发明人: VALLANCE, Patrick John Thompson,St. Martins House , LEIPER, James Mitchell,St. Martins House , WHITLEY, Guy St. John,St. George's Hospital , CHARLES, Ian George,St. Martins House
- 申请人： University College London
- 申请人地址： Gower Street London WC1E 6BT GB
- 专利权人： University College London
- 当前专利权人： University College London
- 当前专利权人地址： Gower Street London WC1E 6BT GB
- 代理机构： Woods, Geoffrey Corlett
- 优先权： GB9901705 19990126; GB9913066 19990604
- 国际公布： WO0044888 20000803
- 主分类号： C12N9/78
- IPC分类号： C12N9/78 ; C12N15/63 ; C07K16/40 ; A01K67/00 ; C12Q1/34 ; A61P3/00 ; A61P13/00 ; A61P9/00 ; A61P25/18 ; A61P21/00 ; A61P19/00
摘要：
Two dimethylarginine dimethylaminohydrolase (DDAH) genes and related genes from Streptomyces coelicolor, Pseudomonas aeruginosa and Mycobacterium tuberculosis have been cloned from humans. These genes and related genes Streptomyces coelicolor, Pseudomonas aeruginosa and Mycobacterium tuberculosis can be used to screen for inhibitors and activators of activity and/or expression of DDAHs. Inhibitors and activators of activity and/or expression of DDAHs are useful in the treatment of conditions in which abnormal metabolism of nitric oxide is implicated.
公开/授权文献
- EP1144605B1 DIMETHYLARGININE DIMETHYLAMINOHYDROLASES 公开/授权日：2009-12-16
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