发明公开
EP1152054A1 NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME
有权
NEER CARBONYL-REDUKTASE，GEN DAVON UND VERFAHREN DER ANWENDUNG DERSELBEN
- 专利标题： NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME
- 专利标题（中）： NEER CARBONYL-REDUKTASE，GEN DAVON UND VERFAHREN DER ANWENDUNG DERSELBEN
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申请号： EP00977938.0申请日： 2000-11-24
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公开(公告)号： EP1152054A1公开(公告)日： 2001-11-07
- 发明人: KIZAKI, Noriyuki , YAMADA, Yukio , YASOHARA, Yoshihiko , HASEGAWA, Junzo
- 申请人： Kaneka Corporation
- 申请人地址： 2-4, Nakanoshima 3-chome, Kita-ku Osaka-shi, Osaka 530-0005 JP
- 专利权人： Kaneka Corporation
- 当前专利权人： Kaneka Corporation
- 当前专利权人地址： 2-4, Nakanoshima 3-chome, Kita-ku Osaka-shi, Osaka 530-0005 JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP34554199 19991203
- 国际公布： WO0140450 20010607
- 主分类号： C12N9/02
- IPC分类号： C12N9/02 ; C12N15/53 ; C12N9/04 ; C12N1/21 ; C12P7/62
摘要：
A novel polypeptide for producing tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate, a gene encoding the polypeptide, and a method of using the polypeptide, are provided. The polypeptide has an enzyme activity to asymmetrically reduce tert-butyl (S)-6-chloro-5-hydroxy-3-oxohexanoate to tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate. The polypeptide comprises the amino acid sequence represented by SEQ ID NO. 1 in the Sequence Listing, or the amino acid sequence having at least one amino acid substitution, insertion, deletion, or addition thereof.
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