利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

46 条记录 (耗时 0.02 秒)

    PROCESS FOR PREPARING OPTICALLY ACTIVE 2- 6-(HYDROXY-METHYL)-1,3-DIOXAN-4-YL|ACETIC ACID DERIVATIVES
    2.
    发明授权
    PROCESS FOR PREPARING OPTICALLY ACTIVE 2- 6-(HYDROXY-METHYL)-1,3-DIOXAN-4-YL|ACETIC ACID DERIVATIVES 有权
    用于生产光学活性的2-¬6-（羟甲基）-1,3-二恶烷-4-基| ACETIC衍生物（〇一年十二月十九日）

    公开(公告)号：EP1288213B1

    公开(公告)日：2006-11-29

    申请号：EP01936850.5

    申请日：2001-06-05

    申请人： KANEKA CORPORATION

    发明人： NISHIYAMA, Akira ,  HORIKAWA, Miho ,  YASOHARA, Yoshihiko ,  UEYAMA, Noboru ,  INOUE, Kenji

    IPC分类号： C07D319/06 ,  C07C69/675 ,  C07C69/716 ,  C12P7/42

    CPC分类号： C07D319/06 ,  C12P7/42 ,  C12P17/06

    摘要： A process for preparing optically active 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an enolate prepared by reacting an acetic acid ester derivative with a base or a zero-valent metal with (S)-β-hydroxy-η-butyrolactone at a temperature of -30°C or above to thereby obtain a dihydroxyoxohexanoic acid derivative, treating this derivative with an acylating agent in the presence of a base to thereby obtain a monoacylated derivative of dihydroxyoxohexanoic acid, reducing the monoacylated derivative with a microorganism into a monoacylated derivative of trihydroxyhexanoic acid, treating the resulting derivative with an acetal-forming reactant in the presence of an acid catalyst to thereby obtain an acyloxymethyldioxanylacetic acid derivative, and subjecting this derivative to solvolysis in the presence of a base.

    PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3-PYRROLIDINOL
    3.
    发明授权
    PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3-PYRROLIDINOL 失效
    用于生产光学活性的N-苄基-3-吡咯烷醇类

    公开(公告)号：EP0942068B1

    公开(公告)日：2004-08-25

    申请号：EP97946058.1

    申请日：1997-11-26

    申请人： KANEKA CORPORATION

    发明人： YASOHARA, Yoshihiko ,  HASEGAWA, Junzo

    IPC分类号： C12P17/10

    CPC分类号： C12P17/10

    摘要： A process for preparing optically active N-benzyl-3-pyrrolidinol efficiently by reducing N-benzyl-3-pyrrolidinone stereoselectively through an enzymatic reaction. The process is one which comprises the step of treating N-benzyl-3-pyrrolidinone with cells of a microorganism, a culture thereof or a product of treatment thereof to form a reaction fluid and the step of recovering optically active N-benzyl-3-pyrrolidinol from the fluid, and wherein the microorganism is one belonging to the genus Depodascus, Debaryomyces, Cryptococcus, Pichia, Rhodosporidium, Trichosporon, Micrococcus, Komagataella, Ogataea or Zygosaccharomyces.

    PROCESS FOR PRODUCING OPTICALLY ACTIVE PYRIDINEETHANOL DERIVATIVES
    6.
    发明公开
    PROCESS FOR PRODUCING OPTICALLY ACTIVE PYRIDINEETHANOL DERIVATIVES 有权
    VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEN PYRIDINETHANOL-DERIVATEN

    公开(公告)号：EP1116795A1

    公开(公告)日：2001-07-18

    申请号：EP00942359.1

    申请日：2000-06-28

    申请人： KANEKA CORPORATION

    发明人： KAWANO, Shigeru ,  HORIKAWA, Miho ,  YASOHARA, Yoshihiko ,  HASEGAWA, Junzo

    IPC分类号： C12P17/18 ,  C12N9/02 ,  C12P41/00 ,  C12N15/53 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C12N9/0004 ,  C12P17/12 ,  C12P17/18 ,  C12P41/002

    摘要： The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing an enzyme or enzyme source to act on polycyclic acetylpyridine derivatives.
    The present invention also relates to a novel enzyme which can be used in the production method mentioned above, a DNA coding for said enzyme, a recombinant vector having said DNA, and a transformant having said recombinant vector.
    The invention further relates to a method of producing an optically active polycyclic pyridineethanol derivative by causing the above novel enzyme or the above transformant to act on optically inactive polycyclic pyridineethanol derivatives.

    摘要翻译： 本发明涉及一种光学活性吡啶乙醇衍生物的制备方法。 更具体地说，本发明涉及通过使酶或酶源作用于多环乙酰基吡啶衍生物来制备光学活性多环吡啶乙醇衍生物的方法。 本发明还涉及可用于上述制备方法，编码所述酶的DNA，具有所述DNA的重组载体和具有所述重组载体的转化体的新型酶。 本发明还涉及通过使上述新型酶或上述转化体作用于光学活性多环吡啶乙醇衍生物来制备光学活性多环吡啶乙醇衍生物的方法。

    MODIFIED CARBONYL REDUCING ENZYME AND GENE
    10.
    发明公开
    MODIFIED CARBONYL REDUCING ENZYME AND GENE 审中-公开
    改良碳氢化合物酶

    公开(公告)号：EP2980213A1

    公开(公告)日：2016-02-03

    申请号：EP14772782.0

    申请日：2014-03-25

    申请人： Kaneka Corporation

    发明人： MATSUI, Misato ,  ITO, Noriyuki ,  KAWANO, Shigeru ,  YASOHARA, Yoshihiko

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12P7/02

    CPC分类号： C12N9/0006 ,  C12P7/02 ,  C12P7/04 ,  C12Y101/01184

    摘要： An object of the present invention is to modify a wild-type enzyme that is less reactive in the presence of an organic solvent to provide altered carbonyl reductases having better reactivity in the presence of the organic solvent than the wild-type enzyme, and/or to provide transformants producing such reductases. The present inventors have found altered carbonyl reductases having better reactivity in the presence of an organic solvent than the wild-type enzyme, from among a mutant enzyme library prepared by randomly mutating the wild-type enzyme gene, thereby arriving at completion of the present invention.

    摘要翻译： 本发明的目的是修饰在有机溶剂存在下反应性较低的野生型酶，以提供在有机溶剂存在下具有比野生型酶更好反应性的改变的羰基还原酶，和/或 以提供产生这种还原酶的转化体。 本发明人发现在通过随机突变野生型酶基因制备的突变型酶库中，在有机溶剂存在下比野生型酶具有更好的反应性的羰基还原酶，从而达到本发明的完成 。