发明公开
EP1157011A1 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES
审中-公开
4-氨基喹唑啉和喹啉WHAT的抑制作用由酪氨酸激酶介导的信号HAVE
- 专利标题： 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES
- 专利标题（中）： 4-氨基喹唑啉和喹啉WHAT的抑制作用由酪氨酸激酶介导的信号HAVE
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申请号： EP00910695.6申请日： 2000-02-24
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公开(公告)号： EP1157011A1公开(公告)日： 2001-11-28
- 发明人: HIMMELSBACH, Frank , LANGKOPF, Elke , JUNG, Birgit , METZ, Thomas , SOLCA, Flavio , BLECH, Stefan
- 申请人： Boehringer Ingelheim Pharma KG
- 申请人地址： 55216 Ingelheim am Rhein DE
- 专利权人： Boehringer Ingelheim Pharma KG
- 当前专利权人： Boehringer Ingelheim Pharma KG
- 当前专利权人地址： 55216 Ingelheim am Rhein DE
- 代理机构： Laudien, Dieter, Dr.
- 优先权： DE19908567 19990227; DE19911366 19990315; DE19928306 19990621; US149329P 19990817; DE19954816 19991113
- 国际公布： WO0051991 20000908
- 主分类号： C07D239/94
- IPC分类号： C07D239/94 ; C07D215/54 ; A61K31/517 ; A61K31/4706 ; A61P35/00 ; C07F9/40 ; C07D401/12 ; C07D493/12 ; C07D403/12 ; C07D405/12 ; C07D413/12
摘要：
The present invention relates to bicyclic heterocycles of general formula (I), wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.
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