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1.发明公开SUBSTITUIERTE PHENYLAMIDINE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZU IHRER HERSTELLUNG 审中-公开取代phenylamidines，药品含有它们的工艺FOR THEIR
公开(公告)号：EP1255744A1
公开(公告)日：2002-11-13
申请号：EP01903646.6
申请日：2001-01-13
发明人： HIMMELSBACH, Frank , GUTH, Brian
IPC分类号： C07D295/15 , A61K31/495 , A61P7/02
CPC分类号： C07D295/15
摘要： The invention relates to phenylamidines of general formula (I), in which R6 and R7 are as defined in claim 1, the tautomers and stereoisomers thereof, including mixtures and salts thereof, in particular, the physiologically acceptable salts with inorganic or organic acids or bases, which display useful pharmacological properties, preferably antithrombotic effects. The invention further relates to medicaments containing said compounds, the use and methods for production thereof.
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2.发明公开BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权BICYCLISCHE HETEROCYCLEN，DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL，DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP1315720A1
公开(公告)日：2003-06-04
申请号：EP01976108.9
申请日：2001-08-18
IPC分类号： C07D413/12 , C07D498/04 , A61K31/5375 , A61P35/00
CPC分类号： C07D413/12
摘要： The invention relates to bicyclic heterocycles of general formula (I), in which Ra to Rc, A to E, and X are defined as referred to in Claim No. 1, to their tautomers, their stereoisomers, and to their salts, particularly their physiologically compatible salts with inorganic or organic acids or bases, which have valuable pharmacological properties, in particular, an inhibitive effect on the signal transduction imparted by tyrosine kinases. The invention also relates to the use of said bicyclic heterocycles for treating diseases, especially tumor diseases, disorders of the lung and of the respiratory tract, and to the production thereof.
摘要翻译： 本发明涉及通式（I）的双环杂环，其中R a至R c，A至E和X如权利要求1所定义，涉及其互变异构体，其立体异构体及其盐，特别是它们的盐 与无机或有机酸或碱的生理相容性盐，其具有有价值的药理学性质，特别是对由酪氨酸激酶赋予的信号转导的抑制作用。 本发明还涉及所述双环杂环化合物用于治疗疾病，特别是肿瘤疾病，肺和呼吸道疾病及其生产的用途。
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3.发明公开CHINAZOLIN DERIVATE , DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 审中-公开喹唑啉衍生物，药物含有它们，它们的使用和工艺及其
公开(公告)号：EP1315717A1
公开(公告)日：2003-06-04
申请号：EP01962953.4
申请日：2001-08-18
IPC分类号： C07D405/12 , C07D413/12 , C07D413/14 , A61K31/517 , C07D239/94
CPC分类号： C07D405/12 , A61K31/505 , C07D239/94 , C07D413/12 , C07D413/14
摘要： The invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc and n are defined as referred to in Claim No. 1, to their tautomers, their stereoisomers, and to their salts, particularly their physiologically compatible salts with inorganic or organic acids or bases, which have valuable pharmacological properties, in particular, an inhibitive effect on the signal transduction imparted by tyrosine kinases. The invention also relates to the use of said bicyclic heterocycles for treating diseases, especially tumor diseases, disorders of the lung and of the respiratory tract, and to the production thereof.
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4.发明授权SUBSTITUIERTE PHENYLAMIDINE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZU IHRER HERSTELLUNG 失效取代phenylamidines，药品含有它们的工艺FOR THEIR
公开(公告)号：EP0824515B1
公开(公告)日：2001-04-04
申请号：EP96912018.7
申请日：1996-04-18
发明人： HIMMELSBACH, Frank , AUSTEL, Volkhard , LINZ, Günter , PIEPER, Helmut , GUTH, Brian , WEISENBERGER, Johannes
IPC分类号： C07C257/18 , C07D211/74 , C07D211/06 , C07D295/15 , A61K31/155 , A61K31/445 , A61K31/495
CPC分类号： C07D295/15 , C07C257/18 , C07C2601/14 , C07D211/34
摘要： The present invention relates to phenyl amidines of general formula (I), in which R1 to R5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their salts, especially their physiologically acceptable salts with inorganic or organic acids or bases also having valuable pharmacological properties, preferably aggregation-limiting effects. The invention also relates to medicaments containing these compounds, their use and a process for producing them.
摘要翻译： PCT号 PCT / EP96 / 01615秒。 371日期十二月 17，1997年二段。 102（e）中的日期十二月 17，1997年PCT提起1996年4月18日的PCT公布。 号 WO96 / 33970的PCT公布。 日期十月 31，1996The本发明涉及通式（I），其中R 1至R 5如权利要求1，及其互变异构体，其立体异构体和它们的混合物和它们的盐，特别是它们与无机酸或有机酸的生理学可接受的盐中所定义的苯基脒 或碱，以便具有有价值的药理性质，优选聚合限制性的影响，生产它们。
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5.发明授权NEUE AMIDINDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL MIT LTB4-ANTAGONISTISCHER WIRKUNG 失效NEW脒衍生物，生产和使用与LTB4拮抗作用的药物
公开(公告)号：EP0625138B1
公开(公告)日：1999-06-02
申请号：EP93902195.2
申请日：1993-01-14
发明人： ANDERSKEWITZ, Ralf , SCHROMM, Kurt , RENTH, Ernst-Otto , HIMMELSBACH, Frank , BIRKE, Franz , FÜGNER, Armin
IPC分类号： C07C257/18 , A61K31/155 , C07D311/22 , C07D213/78 , A61K31/35 , A61K31/44
CPC分类号： C07D213/78 , C07C257/18 , C07C317/18 , C07C317/22 , C07C317/44 , C07C323/20 , C07C323/62 , C07D307/79 , C07D311/22
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6.发明公开
公开(公告)号：EP1194418A1
公开(公告)日：2002-04-10
申请号：EP00936888.7
申请日：2000-06-16
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , METZ, Thomas , SOLCA, Flavio , JUNG, Birgit , BAUM, Anke
IPC分类号： C07D239/94 , C07D215/54 , C07D405/12 , A61K31/517 , A61P35/00
CPC分类号： C07D405/12 , C07D215/42 , C07D215/54 , C07D239/94 , C07D401/12
摘要： The invention relates to bicyclic heterocycles of general formula (I), in which Ra to Rc, A to E and X are defined as in Claim No. 1, to their tautomers, their stereoisomers and their salts, especially their physiologically compatible salts having inorganic or organic acids or bases. The inventive bicyclic heterocycles comprise valuable pharmacological properties, especially an inhibitory effect on the signal transduction procured by tyrosine kinases. The invention also relates to the use of the inventive bicyclic heterocycles for treating illnesses, especially tumor diseases, diseases of the lung and of the respiratory tract, and relates to the production of the inventive compounds.
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7.发明公开
公开(公告)号：EP1163242A2
公开(公告)日：2001-12-19
申请号：EP00920498.3
申请日：2000-03-14
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , BLECH, Stefan , JUNG, Birgit , METZ, Thomas , SOLCA, Flavio
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to bicyclic heterocyclic compounds of general formula (I) wherein Ra, Rb, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosinekinases, their use in treating diseases, particularly tumour diseases, diseases of the lung and airways and the preparation thereof.
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8.发明公开4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES 审中-公开4-氨基喹唑啉和喹啉WHAT的抑制作用由酪氨酸激酶介导的信号HAVE
公开(公告)号：EP1157011A1
公开(公告)日：2001-11-28
申请号：EP00910695.6
申请日：2000-02-24
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , JUNG, Birgit , METZ, Thomas , SOLCA, Flavio , BLECH, Stefan
IPC分类号： C07D239/94 , C07D215/54 , A61K31/517 , A61K31/4706 , A61P35/00 , C07F9/40 , C07D401/12 , C07D493/12 , C07D403/12 , C07D405/12 , C07D413/12
CPC分类号： C07D401/12 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/517 , C07D215/54 , C07D239/94 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to bicyclic heterocycles of general formula (I), wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.
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9.发明公开BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权BICYCLISCHE HETEROCYCLEN，DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL，DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP1280798A1
公开(公告)日：2003-02-05
申请号：EP01938076.5
申请日：2001-03-31
IPC分类号： C07D405/12 , C07D405/14 , C07D491/10 , C07D498/10 , A61K31/517 , A61K31/47 , C07D498/04 , C07D413/14 , A61P35/00
CPC分类号： C07D401/14 , C07D405/12 , C07D413/14 , C07D491/04
摘要： The invention relates to bicyclic heterocycles of the general formula (I), wherein Ra to Rd, A to C and X are defined as in claims 1 to 5. The invention further relates to the tautomers, stereoisomers and salts thereof, especially the physiologically salts with inorganic or organic acids or bases thereof, having valuable pharmacological properties, especially an inhibitory effect on tyrosine kinase mediated signal transduction. The invention further relates to the use of said compounds for treating diseases, especially tumor diseases, diseases of the lungs and the respiratory tract, and to the production of said compounds.
摘要翻译： 本发明涉及通式（I）的双环杂环，其中R a至R d，A至C和X如权利要求1至5中所定义。本发明还涉及其互变异构体，立体异构体和盐，特别是生理盐 与无机或有机酸或其碱具有有价值的药理学性质，特别是对酪氨酸激酶介导的信号转导的抑制作用。 本发明进一步涉及所述化合物用于治疗疾病，特别是肿瘤疾病，肺和呼吸道疾病以及所述化合物的生产的用途。
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10.发明公开
公开(公告)号：EP1163227A1
公开(公告)日：2001-12-19
申请号：EP00909360.0
申请日：2000-03-14
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , BLECH, Stefan , JUNG, Birgit , METZ, Thomas , SOLCA, Flavio
IPC分类号： C07D239/94 , C07D215/54 , C07D401/12 , C07D413/12 , C07D405/12 , A61K31/517 , A61P35/00
CPC分类号： C07D401/12 , A61K31/517 , C07D215/54 , C07D239/94 , C07D401/14 , C07D403/12 , C07D413/12
摘要： The present invention relates to bicyclic heterocyclic compounds of general formula (I), wherein Ra to Rd, A to D and X are defined as in claims 1 to 8, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in treating diseases, particularly tumour diseases, diseases of the lung and airways and the preparation thereof.
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