发明公开
- 专利标题: IMPROVED AQUEOUS SOLUBILITY PHARMACEUTICAL FORMULATIONS
- 专利标题(中): 具有改进的水中溶解度药物制剂
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申请号: EP00918139.7申请日: 2000-03-20
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公开(公告)号: EP1163234A1公开(公告)日: 2001-12-19
- 发明人: ERKOBONI, David, F. , VLADYKA, Ronald, S., Jr. , STERGIOS, Pamela, R.
- 申请人: FMC CORPORATION
- 申请人地址: 1735 Market Street Philadelphia, PA 19103 US
- 专利权人: FMC CORPORATION
- 当前专利权人: FMC CORPORATION
- 当前专利权人地址: 1735 Market Street Philadelphia, PA 19103 US
- 代理机构: W.P. Thompson & Co.
- 优先权: US125914P 19990324; US149680P 19990819
- 国际公布: WO0056726 20000928
- 主分类号: C07D293/00
- IPC分类号: C07D293/00 ; C07D421/00 ; C07D517/00 ; A01N45/00 ; A01N43/50 ; A61K31/56 ; A61K31/415
摘要:
A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is stabilized by the composition of the formulation, providing long shelf life of the improved composition. This stabilized formulation also provides increased solubility and bioavailability of the active agent. Solutions of the active agent are stabilized by the composition, preventing recrystallization and precipitation of the less soluble, crystalline form of the active agent from aqueous solutions thereof.
公开/授权文献
- EP1163234B1 PHARMACEUTICAL FORMULATIONS WITH IMPROVED AQUEOUS SOLUBILITY 公开/授权日:2005-10-26
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