公开(公告)号：EP1163234A1

公开(公告)日：2001-12-19

申请号：EP00918139.7

申请日：2000-03-20

申请人： FMC CORPORATION

发明人： ERKOBONI, David, F. ,  VLADYKA, Ronald, S., Jr. ,  STERGIOS, Pamela, R.

IPC分类号： C07D293/00 ,  C07D421/00 ,  C07D517/00 ,  A01N45/00 ,  A01N43/50 ,  A61K31/56 ,  A61K31/415

CPC分类号： A61K9/145 ,  A61K9/1617 ,  A61K9/1652 ,  A61K31/496 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is stabilized by the composition of the formulation, providing long shelf life of the improved composition. This stabilized formulation also provides increased solubility and bioavailability of the active agent. Solutions of the active agent are stabilized by the composition, preventing recrystallization and precipitation of the less soluble, crystalline form of the active agent from aqueous solutions thereof.

公开(公告)号：EP1027038A1

公开(公告)日：2000-08-16

申请号：EP98953209.8

申请日：1998-09-30

申请人： FMC CORPORATION

发明人： AUGELLO, Michael ,  VLADYKA, Ronald, S., Jr. ,  DELL, Sheila, M.

IPC分类号： A61K9/20 ,  A61K9/28

CPC分类号： A61K9/1652 ,  A61K9/0056 ,  A61K31/192

摘要： The present invention discloses the taste masking of drugs by wet granulating the drug with a microcrystaline cellulose compositions then spheronizing the granulation into spheres having a smooth uniform surface and a particle size in the range of 1 to 1000 microns.