发明授权
- 专利标题: PHARMACEUTICAL FORMULATIONS WITH IMPROVED AQUEOUS SOLUBILITY
- 专利标题(中): 具有改进的水中溶解度药物制剂
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申请号: EP00918139.7申请日: 2000-03-20
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公开(公告)号: EP1163234B1公开(公告)日: 2005-10-26
- 发明人: ERKOBONI, David, F. , VLADYKA, Ronald, S., Jr. , STERGIOS, Pamela, R.
- 申请人: R.P. Scherer Technologies, Inc.
- 申请人地址: 2030 East Flamingo Road, Suite 260 Las Vegas, Nevada 89119 US
- 专利权人: R.P. Scherer Technologies, Inc.
- 当前专利权人: R.P. Scherer Technologies, Inc.
- 当前专利权人地址: 2030 East Flamingo Road, Suite 260 Las Vegas, Nevada 89119 US
- 代理机构: W.P. Thompson & Co.
- 优先权: US125914P 19990324; US149680P 19990819
- 国际公布: WO2000056726 20000928
- 主分类号: C07D293/00
- IPC分类号: C07D293/00 ; C07D421/00 ; C07D517/00 ; A01N45/00 ; A01N43/50 ; A61K31/56 ; A61K31/415 ; A61K9/14
摘要:
A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally hydrophobic vehicle is described. The amorphous state is stabilized by the composition of the formulation, providing long shelf life of the improved composition. This stabilized formulation also provides increased solubility and bioavailability of the active agent. Solutions of the active agent are stabilized by the composition, preventing recrystallization and precipitation of the less soluble, crystalline form of the active agent from aqueous solutions thereof.
公开/授权文献
- EP1163234A1 IMPROVED AQUEOUS SOLUBILITY PHARMACEUTICAL FORMULATIONS 公开/授权日:2001-12-19
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