发明公开
EP1171624A1 METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE, RECOMBINANT LENTIVIRUS VECTORS
有权
方式和途径SAFE重组慢病毒载体高滴度生产
- 专利标题： METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE, RECOMBINANT LENTIVIRUS VECTORS
- 专利标题（中）： 方式和途径SAFE重组慢病毒载体高滴度生产
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申请号： EP00926354.2申请日： 2000-04-26
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公开(公告)号： EP1171624A1公开(公告)日： 2002-01-16
- 发明人: NALDINI, Luigi , DULL, Thomas , BUKOVSKY, Anatoly , FARSON, Deborah , WITT, Rochelle
- 申请人： CELL GENESYS, INC.
- 申请人地址： 342 Lakeside Drive Foster City, CA 94404 US
- 专利权人： CELL GENESYS, INC.
- 当前专利权人： CELL GENESYS, INC.
- 当前专利权人地址： 342 Lakeside Drive Foster City, CA 94404 US
- 代理机构： Campbell, Patrick John Henry
- 优先权： US131671P 19990429
- 国际公布： WO0066759 20001109
- 主分类号： C12N15/867
- IPC分类号： C12N15/867 ; C12N15/63 ; C12N15/64 ; C12N15/48
摘要：
Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
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