发明公开
- 专利标题： INHIBITION OF HISTONE DEACETYLASE
- 专利标题（中）： 蛋白去乙酰化酶的抑制
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申请号： EP00954830.6申请日： 2000-05-03
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公开(公告)号： EP1173562A2公开(公告)日： 2002-01-23
- 发明人: MACLEOD, Alan, R. , LI, Zuomei , BESTERMAN, Jeffrey, M.
- 申请人： Methylgene, Inc.
- 申请人地址： 7220 Frederick Banting Saint-Laurent, Quebec H4S 2A1 CA
- 专利权人： Methylgene, Inc.
- 当前专利权人： Methylgene, Inc.
- 当前专利权人地址： 7220 Frederick Banting Saint-Laurent, Quebec H4S 2A1 CA
- 代理机构： Grund, Martin, Dr.
- 优先权： US132287P 19990503
- 国际公布： WO0071703 20001130
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; A61K31/7125 ; C07H21/00 ; C12Q1/44 ; G01N33/50 ; C12Q1/68
摘要：
The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.
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