公开(公告)号：EP1173562A2

公开(公告)日：2002-01-23

申请号：EP00954830.6

申请日：2000-05-03

申请人： Methylgene, Inc.

发明人： MACLEOD, Alan, R. ,  LI, Zuomei ,  BESTERMAN, Jeffrey, M.

IPC分类号： C12N15/11 ,  A61K31/7125 ,  C07H21/00 ,  C12Q1/44 ,  G01N33/50 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/3521

摘要： The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.