发明公开
EP1177169A1 DERIVES DE 6- [(ARYL ET HETEROARYL) OXY]METHYL] N APHTALENE-2- CARBOXIMIDAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
审中-公开
6¬（芳基ET杂芳基）OXY甲基萘-2-甲脒衍生物，METHOD FOR THEIR和它们的药物用途
- 专利标题： DERIVES DE 6- [(ARYL ET HETEROARYL) OXY]METHYL] N APHTALENE-2- CARBOXIMIDAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
- 专利标题（英）： 6- [(aryl and heteroaryl)oxy] methyl]naphthalene -2-carboximidamide derivatives, preparation and therapeutic application thereof
- 专利标题（中）： 6¬（芳基ET杂芳基）OXY甲基萘-2-甲脒衍生物，METHOD FOR THEIR和它们的药物用途
-
申请号： EP00922738.0申请日： 2000-04-25
-
公开(公告)号： EP1177169A1公开(公告)日： 2002-02-06
- 发明人: ALCOUFFE, Chantal , BELLEVERGUE, Patrice , DELLAC, Geneviève , LATHAM, Christopher , LASSALLE, Gilbert , MALLART, Sergio , MARTIN, Valérie , MASSON, Christine , MCCORT, Gary
- 申请人： SANOFI-SYNTHELABO
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： SANOFI-SYNTHELABO
- 当前专利权人： SANOFI-SYNTHELABO
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Thouret-Lemaitre, Elisabeth
- 优先权： FR9905632 19990504
- 国际公布： WO0066545 20001109
- 主分类号： C07C257/18
- IPC分类号： C07C257/18 ; C07D213/40 ; A61K31/17 ; A61K31/18 ; A61P7/00 ; C07C275/26 ; C07C275/24 ; C07C311/27 ; C07C311/13 ; C07C311/04 ; C07C279/16 ; C07D213/34 ; C07D215/22 ; C07D215/08 ; C07D277/26 ; C07D277/24 ; A61K31/44 ; A61K31/425 ; C07C311/35 ; C07D213/79 ; C07D277/28
摘要：
The invention concerns compounds of general formula (I) wherein: R1 represents either a hydrogen atom, or an amino group, or a C1-C4 alkyl group, or a C1-C6 alkoxycarbonyl group, or a -OH group; R2 represents either a C1-C6 alkyl group, or a phenyl or benzyl group, or a -CH2Q group, wherein Q is a heterocyclic group; R3 and R5 represent independently of each other for example either a hydrogen atom, or a C1-C4 alkyl group, or a -COOH group; R4 represents either a hydrogen atom, or a C1-C4 alkyl group, or a -(CH2)p-COOR8 group; Z represents either a -CH- group, or a nitrogen atom. The invention also concerns the methods of preparation and therapeutic use of said compounds.
信息查询
