公开(公告)号：EP1177169A1

公开(公告)日：2002-02-06

申请号：EP00922738.0

申请日：2000-04-25

申请人： SANOFI-SYNTHELABO

发明人： ALCOUFFE, Chantal ,  BELLEVERGUE, Patrice ,  DELLAC, Geneviève ,  LATHAM, Christopher ,  LASSALLE, Gilbert ,  MALLART, Sergio ,  MARTIN, Valérie ,  MASSON, Christine ,  MCCORT, Gary

IPC分类号： C07C257/18 ,  C07D213/40 ,  A61K31/17 ,  A61K31/18 ,  A61P7/00 ,  C07C275/26 ,  C07C275/24 ,  C07C311/27 ,  C07C311/13 ,  C07C311/04 ,  C07C279/16 ,  C07D213/34 ,  C07D215/22 ,  C07D215/08 ,  C07D277/26 ,  C07D277/24 ,  A61K31/44 ,  A61K31/425 ,  C07C311/35 ,  C07D213/79 ,  C07D277/28

CPC分类号： C07D213/40 ,  C07C311/07 ,  C07C311/09 ,  C07C311/13 ,  C07C311/27 ,  C07C311/35 ,  C07C317/28 ,  C07C323/44 ,  C07D213/34 ,  C07D213/79 ,  C07D215/08 ,  C07D215/227 ,  C07D277/24 ,  C07D277/26 ,  C07D277/28 ,  C07D295/26

摘要： The invention concerns compounds of general formula (I) wherein: R1 represents either a hydrogen atom, or an amino group, or a C1-C4 alkyl group, or a C1-C6 alkoxycarbonyl group, or a -OH group; R2 represents either a C1-C6 alkyl group, or a phenyl or benzyl group, or a -CH2Q group, wherein Q is a heterocyclic group; R3 and R5 represent independently of each other for example either a hydrogen atom, or a C1-C4 alkyl group, or a -COOH group; R4 represents either a hydrogen atom, or a C1-C4 alkyl group, or a -(CH2)p-COOR8 group; Z represents either a -CH- group, or a nitrogen atom. The invention also concerns the methods of preparation and therapeutic use of said compounds.