发明公开
- 专利标题: Method for producing camphorsultam
- 专利标题(中): Verfahren zur Herstellung von Kamphersultam
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申请号: EP01117085.9申请日: 2001-07-13
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公开(公告)号: EP1182198A1公开(公告)日: 2002-02-27
- 发明人: Shiratani, Hiroshi, Sumika Fine Chemicals Co., Ltd , Yamasaki, Shigeya, Sumika Fine Chemicals Co.,Ltd
- 申请人: SUMIKA FINE CHEMICALS Co., Ltd. , ONO PHARMACEUTICAL CO., LTD.
- 申请人地址: 1-21, Utajima-3-chome, Nishiyodogawa-ku Osaka-shi, Osaka 555-0021 JP
- 专利权人: SUMIKA FINE CHEMICALS Co., Ltd.,ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人: SUMIKA FINE CHEMICALS Co., Ltd.,ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 1-21, Utajima-3-chome, Nishiyodogawa-ku Osaka-shi, Osaka 555-0021 JP
- 代理机构: von Kreisler, Alek, Dipl.-Chem.
- 优先权: JP2000253083 20000823
- 主分类号: C07D275/06
- IPC分类号: C07D275/06
摘要:
A method for producing camphorsultam, which includes the following steps 1 to 4:
Step 1: reacting camphorsulfonic acid with a halogenation agent to give camphorsulfonyl halide,
Step 2: reacting the camphorsulfonyl halide with ammonia to give camphorsulfonamide,
Step 3: subjecting the camphorsulfonamide to dehydration and ring closure to give camphorsulfonimine, and
Step 4: reducing the camphorsulfonimine with sodium borohydride in an aqueous isopropanol solution. According to this invention, camphorsultam and intermediates thereof can be obtained by an industrial method which is comparatively safe to the environment and human body, economical, and which is simple and easy.
Step 1: reacting camphorsulfonic acid with a halogenation agent to give camphorsulfonyl halide,
Step 2: reacting the camphorsulfonyl halide with ammonia to give camphorsulfonamide,
Step 3: subjecting the camphorsulfonamide to dehydration and ring closure to give camphorsulfonimine, and
Step 4: reducing the camphorsulfonimine with sodium borohydride in an aqueous isopropanol solution. According to this invention, camphorsultam and intermediates thereof can be obtained by an industrial method which is comparatively safe to the environment and human body, economical, and which is simple and easy.
公开/授权文献
- EP1182198B1 Method for producing camphorsultam 公开/授权日:2004-10-06
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