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    Method for producing camphorsultam
    1.
    发明公开
    Method for producing camphorsultam 有权
    Verfahren zur Herstellung von Kamphersultam

    公开(公告)号：EP1182198A1

    公开(公告)日：2002-02-27

    申请号：EP01117085.9

    申请日：2001-07-13

    申请人： SUMIKA FINE CHEMICALS Co., Ltd. ,  ONO PHARMACEUTICAL CO., LTD.

    发明人： Shiratani, Hiroshi, Sumika Fine Chemicals Co., Ltd ,  Yamasaki, Shigeya, Sumika Fine Chemicals Co.,Ltd

    IPC分类号： C07D275/06

    CPC分类号： C07D275/06

    摘要： A method for producing camphorsultam, which includes the following steps 1 to 4:

    Step 1: reacting camphorsulfonic acid with a halogenation agent to give camphorsulfonyl halide,
    Step 2: reacting the camphorsulfonyl halide with ammonia to give camphorsulfonamide,
    Step 3: subjecting the camphorsulfonamide to dehydration and ring closure to give camphorsulfonimine, and
    Step 4: reducing the camphorsulfonimine with sodium borohydride in an aqueous isopropanol solution. According to this invention, camphorsultam and intermediates thereof can be obtained by an industrial method which is comparatively safe to the environment and human body, economical, and which is simple and easy.

    摘要翻译： 制备樟脑磺酸的方法，其包括以下步骤1至4：步骤1：使樟脑磺酸与卤化剂反应得到樟脑磺酰卤，步骤2：使樟脑磺酰卤与氨反应得到樟脑磺酰胺，步骤3：使樟脑磺酰胺 脱水和闭环以得到樟脑磺酰亚胺，步骤4：用异丙醇水溶液中的硼氢化钠还原樟脑磺酰亚胺。 根据本发明，樟脑磺胺及其中间体可以通过对环境和人体相对安全的工业方法获得，经济且简单易行。