发明授权
EP1183256B1 DERIVES DE LA PURINE, LEUR PROCEDE DE PREPARATION, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
有权
嘌呤衍生物，METHOD FOR THEIR AND YOU药物组合物含
- 专利标题： DERIVES DE LA PURINE, LEUR PROCEDE DE PREPARATION, ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
- 专利标题（英）： Purine derivatives, preparation method and pharmaceutical compositions containing same
- 专利标题（中）： 嘌呤衍生物，METHOD FOR THEIR AND YOU药物组合物含
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申请号： EP00929625.2申请日： 2000-05-18
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公开(公告)号： EP1183256B1公开(公告)日： 2007-08-22
- 发明人: HAESSLEIN, Jean-Luc
- 申请人： Aventis Pharma S.A.
- 申请人地址： 20, avenue Raymond Aron 92160 Antony FR
- 专利权人： Aventis Pharma S.A.
- 当前专利权人： Aventis Pharma S.A.
- 当前专利权人地址： 20, avenue Raymond Aron 92160 Antony FR
- 代理机构： Vieillefosse, Jean-Claude
- 优先权： FR9906456 19990521
- 国际公布： WO2000071543 20001130
- 主分类号： C07D473/16
- IPC分类号： C07D473/16 ; C07D473/40 ; A61K31/52 ; A61P25/28
摘要：
The invention concerns novel products of formula (I), wherein: Z represents -CH2-, -SO2-, -CO-, -COO-, -CONH- or -(CH2)2-NR3-; n represents 0 or 1; R1 represents hydrogen, aryl, -CH2-aryl, -SO2-aryl, -CO-aryl, heterocyclic, -CH2- heterocyclic, alkyl and -SO2-alkyl; R2 represents alkyl, cycloalkyl or heterocycle containing oxygen, sulphur or NR3; Y represents oxygen, sulphur or NR3; D1 and D2 are either selected among hydrogen, hydroxyl, alkyl, alkoxy and NHR5, or form =O, or =N-OR4; R3 represents hydrogen, alkyl or cycloalkyl; R4 represents hydrogen, alkyl, cycloalkyl or aryl; R5 represents hydrogen, alkyl, cycloalkyl or -COOtbu; R6 represents hydrogen, halogen, hydroxyl, alkyl, alkoxy or NHR3; said products being all in isomeric forms and their salts, as medicines.
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