公开(公告)号：EP1261603A1

公开(公告)日：2002-12-04

申请号：EP01909906.8

申请日：2001-02-27

申请人： Aventis Pharma S.A.

发明人： HAESSLEIN, Jean-Luc ,  LEFRANCOIS, Dominique ,  URIDAT, Eric ,  ZHANG, Jidong

IPC分类号： C07D405/04 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/453 ,  A61P35/00

CPC分类号： C07D409/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14

摘要： The invention concerns novel products of formula (I) wherein: R1 represents a carbocyclic or heterocyclic radical optionally substituted; R2 and R3 are such that one represents hydrogen and the other represents piperidinyl optionally substituted; R4 represents hydrogen, alkyl or phenyl optionally substituted, said products being in all isomeric and salt forms and used as medicines.

公开(公告)号：EP1183256B1

公开(公告)日：2007-08-22

申请号：EP00929625.2

申请日：2000-05-18

申请人： Aventis Pharma S.A.

发明人： HAESSLEIN, Jean-Luc

IPC分类号： C07D473/16 ,  C07D473/40 ,  A61K31/52 ,  A61P25/28

CPC分类号： C07D473/00 ,  A61K31/52

摘要： The invention concerns novel products of formula (I), wherein: Z represents -CH2-, -SO2-, -CO-, -COO-, -CONH- or -(CH2)2-NR3-; n represents 0 or 1; R1 represents hydrogen, aryl, -CH2-aryl, -SO2-aryl, -CO-aryl, heterocyclic, -CH2- heterocyclic, alkyl and -SO2-alkyl; R2 represents alkyl, cycloalkyl or heterocycle containing oxygen, sulphur or NR3; Y represents oxygen, sulphur or NR3; D1 and D2 are either selected among hydrogen, hydroxyl, alkyl, alkoxy and NHR5, or form =O, or =N-OR4; R3 represents hydrogen, alkyl or cycloalkyl; R4 represents hydrogen, alkyl, cycloalkyl or aryl; R5 represents hydrogen, alkyl, cycloalkyl or -COOtbu; R6 represents hydrogen, halogen, hydroxyl, alkyl, alkoxy or NHR3; said products being all in isomeric forms and their salts, as medicines.

公开(公告)号：EP1347975A1

公开(公告)日：2003-10-01

申请号：EP01994897.5

申请日：2001-12-19

申请人： Aventis Pharma S.A.

发明人： BORDON-PALLIER, Florence ,  HAESSLEIN, Jean-Luc

IPC分类号： C07D473/16 ,  C07D473/40 ,  A61K31/52 ,  A61P31/00

CPC分类号： C07D473/16 ,  C07D473/40

摘要： The invention concerns novel products of formula (I), wherein: Rx represents -(Z)n-R1 with Z representing in particular -CH2- or -(CH2)2-NH; n represents the integer 0 or 1 and R1 represents in particular hydrogen, phenyl, -CH2-phenyl, pyridyl, alkyl, piperidinyl optionally substituted; Ry represents the radical (II), wherein: D1 and D2 represent in particular hydrogen and -NH2 optionally substituted, said products being in all the isomeric forms and salts, as medicines.

公开(公告)号：EP1183256A1

公开(公告)日：2002-03-06

申请号：EP00929625.2

申请日：2000-05-18

申请人： Aventis Pharma S.A.

发明人： HAESSLEIN, Jean-Luc

IPC分类号： C07D473/16 ,  C07D473/40 ,  A61K31/52 ,  A61P25/28

CPC分类号： C07D473/00 ,  A61K31/52

摘要： The invention concerns novel products of formula (I), wherein: Z represents -CH2-, -SO2-, -CO-, -COO-, -CONH- or -(CH2)2-NR3-; n represents 0 or 1; R1 represents hydrogen, aryl, -CH2-aryl, -SO2-aryl, -CO-aryl, heterocyclic, -CH2- heterocyclic, alkyl and -SO2-alkyl; R2 represents alkyl, cycloalkyl or heterocycle containing oxygen, sulphur or NR3; Y represents oxygen, sulphur or NR3; D1 and D2 are either selected among hydrogen, hydroxyl, alkyl, alkoxy and NHR5, or form =O, or =N-OR4; R3 represents hydrogen, alkyl or cycloalkyl; R4 represents hydrogen, alkyl, cycloalkyl or aryl; R5 represents hydrogen, alkyl, cycloalkyl or -COOtbu; R6 represents hydrogen, halogen, hydroxyl, alkyl, alkoxy or NHR3; said products being all in isomeric forms and their salts, as medicines.

公开(公告)号：EP1261603B1

公开(公告)日：2006-08-16

申请号：EP01909906.8

申请日：2001-02-27

申请人： Aventis Pharma S.A.

发明人： HAESSLEIN, Jean-Luc ,  LEFRANCOIS, Dominique ,  URIDAT, Eric ,  ZHANG, Jidong

IPC分类号： C07D405/04 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/453 ,  A61P35/00

CPC分类号： C07D409/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14

摘要： The invention concerns novel products of formula (I) wherein: R1 represents a carbocyclic or heterocyclic radical optionally substituted; R2 and R3 are such that one represents hydrogen and the other represents piperidinyl optionally substituted; R4 represents hydrogen, alkyl or phenyl optionally substituted, said products being in all isomeric and salt forms and used as medicines.

公开(公告)号：EP1597258A2

公开(公告)日：2005-11-23

申请号：EP04710901.2

申请日：2004-02-13

申请人： Aventis Pharma S.A.

发明人： BORDON-PALLIER, Florence ,  HAESSLEIN, Jean-Luc

IPC分类号： C07D473/34 ,  A61K31/52 ,  A61P31/10 ,  A61P25/28 ,  A61P35/00 ,  A61P25/34

CPC分类号： C07D473/16

摘要： The invention relates to novel products having formula (I), wherein: Y represents N, O, S, CHR3 or =CR3; the dotted lines represent a single or double bond; R and R1 represent, in particular, H, Hal, OH, alkyl, alkoxy, cyano, NO2, NR4R5, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, -S(O)n-NR4R5, whereby n represents 0 to 2, acyl, -NH-CO-alkyl or -NH-CO-NH-phenyl; R3 represents H, Hal, alkyl, cyano, NO2, NR4R5, trifluoromethyl or aryl; R2 represents R4, OR4, SR4 or NR4R5; and R4 represents H, alkyl, cycloalkyl or aryl. According to the invention, either R4 and R5 are selected from among the values of R4, or R4 and R5, together with N, form a heterocyclic radical which can contain N, 0 and S, all of said radicals being optionally substituted. Moreover, the aforementioned products take all of the isomeric and salt forms for use as medicaments.

公开(公告)号：EP1045856B1

公开(公告)日：2003-04-09

申请号：EP99900500.2

申请日：1999-01-07

申请人： Aventis Pharma S.A.

发明人： HAESSLEIN, Jean-Luc ,  KLICH, Michel ,  LAURIN, Patrick ,  MUSICKI, Branislav ,  PERIERS, Anne-Marie

IPC分类号： C07H17/075 ,  A61K31/70

CPC分类号： C07H17/075

公开(公告)号：EP1597258B1

公开(公告)日：2008-11-05

申请号：EP04710901.2

申请日：2004-02-13

申请人： Aventis Pharma S.A.

发明人： BORDON-PALLIER, Florence ,  HAESSLEIN, Jean-Luc

IPC分类号： C07D473/34 ,  A61K31/52 ,  A61P31/10 ,  A61P25/28 ,  A61P35/00 ,  A61P25/34

CPC分类号： C07D473/16

摘要： The invention relates to novel products having formula (I), wherein: Y represents N, O, S, CHR3 or =CR3; the dotted lines represent a single or double bond; R and R1 represent, in particular, H, Hal, OH, alkyl, alkoxy, cyano, NO2, NR4R5, trifluoromethyl, trifluoromethoxy, aryl, heteroaryl, -S(O)n-NR4R5, whereby n represents 0 to 2, acyl, -NH-CO-alkyl or -NH-CO-NH-phenyl; R3 represents H, Hal, alkyl, cyano, NO2, NR4R5, trifluoromethyl or aryl; R2 represents R4, OR4, SR4 or NR4R5; and R4 represents H, alkyl, cycloalkyl or aryl. According to the invention, either R4 and R5 are selected from among the values of R4, or R4 and R5, together with N, form a heterocyclic radical which can contain N, 0 and S, all of said radicals being optionally substituted. Moreover, the aforementioned products take all of the isomeric and salt forms for use as medicaments.

公开(公告)号：EP0579819B1

公开(公告)日：2005-12-21

申请号：EP93905369.0

申请日：1993-02-05

申请人： Aventis Pharma S.A.

发明人： FORTIN, Michel ,  HAESSLEIN, Jean-Luc ,  HECKMANN, Bertrand

IPC分类号： C07D211/86 ,  C07D401/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/10 ,  A61K31/44 ,  C07D309/30 ,  C07D309/32

CPC分类号： C07D213/70 ,  C07D213/68 ,  C07D213/79 ,  C07D401/10

摘要： Products of formula (I), wherein R1, R2, R3 and R4 are a hydrogen atom, a halogen atom, or a hydroxyl, mercapto, cyano, nitro, sulpho, formyl, benzoyl, acyl, carboxy, cycloalkyl or acyloxy radical; an alkyl, alkenyl, alkynyl, alkyloxy or alkylthio radical; an aryl, arylalkyl, arylalkenyl, aryloxy or arylthio radical; a radical (a), (b) or (c); a radical -(CH2)m1-S(O)m2-Z'-R'14 wherein m1 is an integer from 0 to 4, m2 is an integer from 0 to 2, R5 is a divalent alkylene radical, and Y is a radical -Y1-B-Y2. The products have interesting pharmacological properties which justify their use as drugs.