发明公开
EP1185232A1 METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS
审中-公开
方法脱发的治疗中使用甲磺酰基含拟甲状腺素CONNECTIONS
- 专利标题: METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS
- 专利标题(中): 方法脱发的治疗中使用甲磺酰基含拟甲状腺素CONNECTIONS
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申请号: EP00915939.3申请日: 2000-03-01
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公开(公告)号: EP1185232A1公开(公告)日: 2002-03-13
- 发明人: ZHANG, Lilly, Li-Xin , YOUNGQUIST, Robert, Scott
- 申请人: UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER
- 申请人地址: 5323 Harry Hines Boulevard Dallas, TX 75235-9094 US
- 专利权人: UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER
- 当前专利权人: UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER
- 当前专利权人地址: 5323 Harry Hines Boulevard Dallas, TX 75235-9094 US
- 代理机构: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät
- 优先权: US137023P 19990601
- 国际公布: WO0072810 20001207
- 主分类号: A61K7/06
- IPC分类号: A61K7/06
摘要:
A method of treating hair loss comprising administering a composition comprising a cardiac-sparing compound characterized by structure (I) and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein: R1 is -(CH2)n(CHNR7R8)mC(O)R9; n is an integer from 1 to 3; m is an integer from 0 to 1; R3 and R5 are each, independently, selected from the group consisting of chlorine, bromine, iodine, and -CH3, R7 and R8 are each, independently, selected from the group consisting of hydrogen and C1-C4 alkyl; R9 is selected from the group consisting of hydroxy, C1-C4 alkoxy, and -NR7R8; R31 is selected from the group consisting of hydrogen, chlorine, bromine, iodine, C1-C4 alkyl, C4-C6 cycloalkyl, C1-C4 haloalkyl, C4-C6 halocycloalkyl, and -CH(R10)Ar; Ar is selected from the group consisting of 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methoxypyridazin-3-yl N-oxide, and 6-hydroxypyridazin-3-yl N-oxide; R10 is selected from the group consisting of hydrogen and C1-C4 alkyl; and R41 is selected from the group consisting of hydroxy and C1-C4 alkoxy.
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