公开(公告)号：EP1185229A1

公开(公告)日：2002-03-13

申请号：EP00913675.5

申请日：2000-03-01

申请人： UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

发明人： ZHANG, Lixin, Lilly ,  YOUNGQUIST, Robert, Scott

IPC分类号： A61K7/06 ,  A61K31/085 ,  A61K31/09

CPC分类号： A61K8/494 ,  A61K8/365 ,  A61K8/44 ,  A61K8/4926 ,  A61K31/085 ,  A61K31/09 ,  A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61Q7/00

摘要： The present disclosure describes methods for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The methods comprise administering a cardiac-sparing coumpound having a structure as described herein and a pharmaceutically-acceptable carrier.

公开(公告)号：EP1185232A1

公开(公告)日：2002-03-13

申请号：EP00915939.3

申请日：2000-03-01

申请人： UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

发明人： ZHANG, Lilly, Li-Xin ,  YOUNGQUIST, Robert, Scott

IPC分类号： A61K7/06

CPC分类号： A61Q7/00 ,  A61K8/46 ,  A61K8/4953

摘要： A method of treating hair loss comprising administering a composition comprising a cardiac-sparing compound characterized by structure (I) and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein: R1 is -(CH2)n(CHNR7R8)mC(O)R9; n is an integer from 1 to 3; m is an integer from 0 to 1; R3 and R5 are each, independently, selected from the group consisting of chlorine, bromine, iodine, and -CH3, R7 and R8 are each, independently, selected from the group consisting of hydrogen and C1-C4 alkyl; R9 is selected from the group consisting of hydroxy, C1-C4 alkoxy, and -NR7R8; R31 is selected from the group consisting of hydrogen, chlorine, bromine, iodine, C1-C4 alkyl, C4-C6 cycloalkyl, C1-C4 haloalkyl, C4-C6 halocycloalkyl, and -CH(R10)Ar; Ar is selected from the group consisting of 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methoxypyridazin-3-yl N-oxide, and 6-hydroxypyridazin-3-yl N-oxide; R10 is selected from the group consisting of hydrogen and C1-C4 alkyl; and R41 is selected from the group consisting of hydroxy and C1-C4 alkoxy.

公开(公告)号：EP1185230A1

公开(公告)日：2002-03-13

申请号：EP00913677.1

申请日：2000-03-01

申请人： UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

发明人： ZHANG, Lilly, Li-Xin ,  YOUNGQUIST, Robert, Scott

IPC分类号： A61K7/06 ,  A61P17/14

CPC分类号： A61K8/44 ,  A61Q7/00

摘要： The present disclosure describes methods for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The methods comprise administering a cardiac-sparing compound having a structure of formula (I) as described herein and a pharmaceutically-acceptable carrier.

公开(公告)号：EP1194422A1

公开(公告)日：2002-04-10

申请号：EP00915935.1

申请日：2000-03-01

申请人： UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

发明人： YOUNGQUIST, Robert, Scott ,  MCIVER, John, McMillan

IPC分类号： C07D295/08 ,  C07C233/25 ,  C07C233/29 ,  A61K31/165 ,  A61P17/14 ,  A61K31/535 ,  A61K31/40

CPC分类号： A61K8/411 ,  A61K8/49 ,  A61K8/4913 ,  A61Q7/00 ,  C07C215/74 ,  C07C217/82 ,  C07C233/25 ,  C07C233/33 ,  C07C233/76 ,  C07D295/096 ,  C07D295/112

摘要： The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds have a biphenyl structure as described in formula (I) and are preferably cardiac-sparing, and pharmaceutically acceptable salts, hydrates and biohydrolyzable amides, esters, and imides thereof, wherein, R1, R2, R3, R4, R5, R6, R6', R7, R8, R9, R10, Y, X, R11, and R12 are defined herein.

公开(公告)号：EP1194405A1

公开(公告)日：2002-04-10

申请号：EP00914768.7

申请日：2000-03-01

申请人： UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

发明人： YOUNGQUIST, Robert, Scott ,  MCIVER, John, McMillan

IPC分类号： C07C323/37 ,  C07C317/34 ,  A61K7/06

CPC分类号： C07D295/096 ,  A61K8/46 ,  A61K8/49 ,  A61K8/4913 ,  A61Q7/00 ,  C07C317/40 ,  C07C323/37 ,  C07C323/41 ,  C07C323/42

摘要： The present disclosure describes novel compounds of formula (A), wherein R1-R12, X and Y have the meanings given in the specification and compositions containing them which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds described herein are cardiac-sparing.

公开(公告)号：EP1183074A1

公开(公告)日：2002-03-06

申请号：EP00913676.3

申请日：2000-03-01

申请人： UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

发明人： YOUNGQUIST, Robert, Scott ,  MCIVER, John, McMillan

IPC分类号： A61P17/14 ,  C07C233/25 ,  C07C233/29 ,  C07D295/08 ,  A61K31/165 ,  A61K31/535 ,  A61K31/40

CPC分类号： C07D295/096 ,  C07C217/90 ,  C07C233/25 ,  C07C233/75 ,  C07C237/20 ,  C07C271/22

摘要： The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds have a biphenyl structure as described herein and are preferably cardiac-sparing.